MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Gene Ontology	Class	Gene	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 318 to 367 of 2667 in total

Regulation  : down

Ratio	description	Gene Ontology	Class
1.30082	CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2). [Uniprot/SWISSPROT;Acc:Q9NZN8]	RNA polymerase II transcription mediator activity	molecular function
		transcription regulator activity
1.30142	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen). [Uniprot/SWISSPROT;Acc:P22607]	ATP binding
		cell growth	biological process
		fibroblast growth factor receptor activity	molecular function
		fibroblast growth factor receptor signaling pathway	biological process
		forebrain development
		hair cell differentiation
		identical protein binding	molecular function
		inner ear development	biological process
		integral to membrane	cellular component
		integral to plasma membrane
		interleukin-1 receptor activity	molecular function
		internal side of plasma membrane	cellular component
		JAK-STAT cascade	biological process
		lysosome	cellular component
		MAPKKK cascade	biological process
		membrane	cellular component
		morphogenesis of an epithelium	biological process
		negative regulation of epithelial cell proliferation
		nucleotide binding	molecular function
		perinuclear region of cytoplasm	cellular component
		positive regulation of apoptosis	biological process
		positive regulation of cell differentiation
		positive regulation of peptidyl-tyrosine phosphorylation
		positive regulation of protein ubiquitination
		protein amino acid phosphorylation
		protein kinase activity	molecular function
		protein serine/threonine kinase activity
		protein-tyrosine kinase activity
		receptor activity
		sensory perception of sound	biological process
		skeletal development
		transferase activity	molecular function
1.30207	Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein). [Uniprot/SWISSPROT;Acc:Q5SW96]	AP-1 adaptor complex	cellular component
		AP-2 adaptor complex
		basal plasma membrane
		cholesterol homeostasis	biological process
		cholesterol metabolic process
		clathrin binding	molecular function
		cytoplasm	cellular component
		cytosol
		early endosome
		endocytosis	biological process
		lipid metabolic process
		phosphotyrosine binding	molecular function
		positive regulation of receptor mediated endocytosis	biological process
		protein binding	molecular function
		protein binding, bridging
		protein C-terminus binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.