Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Gene Ontology Ratio Regulation Class description Gene Minimum Ratio Accession Maximum Ratio

Results: HTML CSV LaTeX

Showing element 305 to 354 of 2667 in total

Gene Ontology	Ratio	Regulation	Class	description
chloride ion binding	1.31661	up	molecular function	Chloride anion exchanger (Protein DRA) (Down-regulated in adenoma) (Solute carrier family 26 member 3). [Uniprot/SWISSPROT;Acc:P40879]
chloride transport	1.5415	down	biological process	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta). [Uniprot/SWISSPROT;Acc:Q86SQ0]
cholesterol biosynthetic process	1.43088			Isopentenyl-diphosphate Delta-isomerase 2 (EC 5.3.3.2) (IPP isomerase 2) (Isopentenyl pyrophosphate isomerase 2) (IPPI2). [Uniprot/SWISSPROT;Acc:Q9BXS1]
cholesterol homeostasis	1.30207			Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein). [Uniprot/SWISSPROT;Acc:Q5SW96]
cholesterol metabolic process	1.23845			Insulin-induced gene 1 protein (INSIG-1). [Uniprot/SWISSPROT;Acc:O15503]
cholesterol metabolic process	1.30207			Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein). [Uniprot/SWISSPROT;Acc:Q5SW96]
cholinesterase activity	2.54508	up	molecular function	Neuroligin-2 precursor. [Uniprot/SWISSPROT;Acc:Q8NFZ4]
chromatin	1.25808	up	cellular component	Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Uniprot/SWISSPROT;Acc:Q9P2D1]
	1.60746	down		Chromodomain-helicase-DNA-binding protein 6 (EC 3.6.1.-) (ATP- dependent helicase CHD6) (CHD-6) (Radiation-induced gene B protein). [Uniprot/SWISSPROT;Acc:Q8TD26]
	1.78439	up		Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta). [Uniprot/SWISSPROT;Acc:Q14839]
	2.72371			Opa-interacting protein 5. [Uniprot/SWISSPROT;Acc:O43482]
	4.55177			Transcription factor SOX-14. [Uniprot/SWISSPROT;Acc:O95416]
chromatin assembly or disassembly	1.25808		biological process	Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Uniprot/SWISSPROT;Acc:Q9P2D1]
	1.60746	down		Chromodomain-helicase-DNA-binding protein 6 (EC 3.6.1.-) (ATP- dependent helicase CHD6) (CHD-6) (Radiation-induced gene B protein). [Uniprot/SWISSPROT;Acc:Q8TD26]
	1.78439	up		Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta). [Uniprot/SWISSPROT;Acc:Q14839]
chromatin binding	1.25808	up	molecular function	Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Uniprot/SWISSPROT;Acc:Q9P2D1]
	1.60746	down		Chromodomain-helicase-DNA-binding protein 6 (EC 3.6.1.-) (ATP- dependent helicase CHD6) (CHD-6) (Radiation-induced gene B protein). [Uniprot/SWISSPROT;Acc:Q8TD26]
	1.78439	up		Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta). [Uniprot/SWISSPROT;Acc:Q14839]
	2.29381	up		Ataxin-7 (Spinocerebellar ataxia type 7 protein). [Uniprot/SWISSPROT;Acc:O15265]
	3.29064	down		Transcription factor GATA-6 (GATA-binding factor 6). [Uniprot/SWISSPROT;Acc:Q92908]
chromatin modification	1.25808	up	biological process	Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Uniprot/SWISSPROT;Acc:Q9P2D1]
	1.78439	up		Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta). [Uniprot/SWISSPROT;Acc:Q14839]
	4.49282	down		Enhancer of polycomb homolog 1. [Uniprot/SWISSPROT;Acc:Q9H2F5]
chromatin remodeling	1.60746			Chromodomain-helicase-DNA-binding protein 6 (EC 3.6.1.-) (ATP- dependent helicase CHD6) (CHD-6) (Radiation-induced gene B protein). [Uniprot/SWISSPROT;Acc:Q8TD26]
chromatin remodeling	5.83544			Nucleoplasmin-2. [Uniprot/SWISSPROT;Acc:Q86SE8]
chromocenter	2.72371	up	cellular component	Opa-interacting protein 5. [Uniprot/SWISSPROT;Acc:O43482]
chromosome	1.78708			Centromere protein L (CENP-L) (Interphase centromere complex protein 33). [Uniprot/SWISSPROT;Acc:Q8N0S6]
	2.7017			Centromere protein S (CENP-S) (Apoptosis-inducing TAF9-like domain- containing protein 1). [Uniprot/SWISSPROT;Acc:Q8N2Z9]
	2.86965			RNA-binding protein 28 (RNA-binding motif protein 28). [Uniprot/SWISSPROT;Acc:Q9NW13]
chromosome organization and biogenesis (sensu Eukaryota)	1.78439		biological process	Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta). [Uniprot/SWISSPROT;Acc:Q14839]
chromosome organization and biogenesis (sensu Eukaryota)	2.7017		biological process	Centromere protein S (CENP-S) (Apoptosis-inducing TAF9-like domain- containing protein 1). [Uniprot/SWISSPROT;Acc:Q8N2Z9]
chromosome, pericentric region	1.73211	down	cellular component	Antigen KI-67. [Uniprot/SWISSPROT;Acc:P46013]
	1.78708	up		Centromere protein L (CENP-L) (Interphase centromere complex protein 33). [Uniprot/SWISSPROT;Acc:Q8N0S6]
	2.7017	up		Centromere protein S (CENP-S) (Apoptosis-inducing TAF9-like domain- containing protein 1). [Uniprot/SWISSPROT;Acc:Q8N2Z9]
ciliary or flagellar motility	1.29424	down	biological process	Calcyphosin-2 (Calcyphosine-2). [Uniprot/SWISSPROT;Acc:Q9BXY5]
ciliary or flagellar motility	1.61347	down	biological process	Calmodulin-like protein 5 (Calmodulin-like skin protein). [Uniprot/SWISSPROT;Acc:Q9NZT1]
cilium	1.34491	up	cellular component	Bardet-Biedl syndrome 5 protein. [Uniprot/SWISSPROT;Acc:Q8N3I7]
circulation	1.25808		biological process	Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Uniprot/SWISSPROT;Acc:Q9P2D1]
circulation	1.45624		biological process	Transcription factor NF-E2 45 kDa subunit (Nuclear factor, erythroid- derived 2 45 kDa subunit) (p45 NF-E2) (Leucine zipper protein NF-E2). [Uniprot/SWISSPROT;Acc:Q16621]
clathrin binding	1.30207	down	molecular function	Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein). [Uniprot/SWISSPROT;Acc:Q5SW96]
cofactor binding	8.21788	up	molecular function	Ubiquitin-activating enzyme E1 domain-containing protein 1 (UFM1- activating enzyme) (Ubiquitin-activating enzyme 5) (ThiFP1). [Uniprot/SWISSPROT;Acc:Q9GZZ9]
collagen	1.40749		cellular component	collagen, type XXVII, alpha 1 [RefSeq_peptide;Acc:NP_116277]
collagen binding	1.10831		molecular function	Procollagen C-endopeptidase enhancer 1 precursor (Procollagen COOH- terminal proteinase enhancer 1) (Procollagen C-proteinase enhancer 1) (PCPE-1) (Type I procollagen COOH-terminal proteinase enhancer) (Type 1 procollagen C-proteinase enhancer protein). [Uniprot/SWISSPROT;Acc:Q15113]
complement activation	2.65068		biological process	NULL
condensed chromosome	1.73211	down	cellular component	Antigen KI-67. [Uniprot/SWISSPROT;Acc:P46013]
condensed nuclear chromosome	4.04651	up	cellular component	Sad1/unc-84-like protein 2 (Rab5-interacting protein) (Rab5IP). [Uniprot/SWISSPROT;Acc:Q9UH99]
copper ion binding	1.20102		molecular function	Metalloreductase STEAP3 (EC 1.16.1.-) (Six-transmembrane epithelial antigen of prostate 3) (Tumor suppressor-activated pathway protein 6) (hTSAP6) (pHyde) (hpHyde) (Dudulin-2). [Uniprot/SWISSPROT;Acc:Q658P3]
coreceptor activity	1.25147		molecular function	T-lymphocyte activation antigen CD86 precursor (Activation B7-2 antigen) (CTLA-4 counter-receptor B7.2) (B70) (FUN-1) (BU63). [Uniprot/SWISSPROT;Acc:P42081]
cyclic nucleotide biosynthetic process	1.18489		biological process	Guanylate cyclase soluble subunit beta-2 (EC 4.6.1.2) (GCS-beta-2). [Uniprot/SWISSPROT;Acc:O75343]
cyclooxygenase pathway	1.18096	down	biological process	Prostaglandin G/H synthase 2 precursor (EC 1.14.99.1) (Cyclooxygenase- 2) (COX-2) (Prostaglandin-endoperoxide synthase 2) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (PHS II). [Uniprot/SWISSPROT;Acc:P35354]

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.

- http://analysis.yellowcouch.org/