MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Gene Ontology	Class	Gene	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 301 to 350 of 2667 in total

Ratio	Regulation	description	Gene Ontology	Class
1.19539	up	Cysteine desulfurase, mitochondrial precursor (EC 2.8.1.7). [Uniprot/SWISSPROT;Acc:Q9Y697]	metabolic process	biological process
			mitochondrion	cellular component
			nucleus
			protein complex assembly	biological process
			pyridoxal phosphate binding	molecular function
			sulfur amino acid metabolic process	biological process
			transaminase activity	molecular function
			transferase activity
1.19545		Deoxyribonuclease-2-alpha precursor (EC 3.1.22.1) (Deoxyribonuclease II alpha) (DNase II alpha) (Acid DNase) (Lysosomal DNase II) (R31240_2). [Uniprot/SWISSPROT;Acc:O00115]	apoptosis	biological process
			deoxyribonuclease II activity	molecular function
			DNA binding
			DNA catabolic process	biological process
			DNA metabolic process
			endodeoxyribonuclease activity	molecular function
			endonuclease activity
			erythrocyte differentiation	biological process
			extracellular region	cellular component
			hormone activity	molecular function
			hydrolase activity
			lysosome	cellular component
			multicellular organismal development	biological process
			protein binding	molecular function
1.20102		Metalloreductase STEAP3 (EC 1.16.1.-) (Six-transmembrane epithelial antigen of prostate 3) (Tumor suppressor-activated pathway protein 6) (hTSAP6) (pHyde) (hpHyde) (Dudulin-2). [Uniprot/SWISSPROT;Acc:Q658P3]	apoptosis	biological process
			cell cycle
			copper ion binding	molecular function
			electron transport	biological process
			endosome	cellular component
			FAD binding	molecular function
			ferric-chelate reductase activity
			integral to membrane	cellular component
			ion transport	biological process
			iron ion binding	molecular function
			iron ion transport	biological process
			membrane	cellular component
			metal ion binding	molecular function
			oxidoreductase activity
			plasma membrane	cellular component
1.20481	down	Neurosecretory protein VGF precursor. [Uniprot/SWISSPROT;Acc:O15240]	biological_process	biological process
			cellular_component	cellular component
			cytoplasmic vesicle
			generation of precursor metabolites and energy	biological process
			growth factor activity	molecular function
			neuropeptide hormone activity
			ovarian follicle development	biological process
			sexual reproduction
1.20619		Sodium/potassium-transporting ATPase subunit alpha-4 (EC 3.6.3.9) (Sodium pump subunit alpha-4) (Na(+)/K(+) ATPase alpha-4 subunit). [Uniprot/SWISSPROT;Acc:Q13733]	ATP binding	molecular function
			ATP hydrolysis coupled proton transport	biological process
			ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	molecular function
			catalytic activity
			cation transport	biological process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.