MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Accession	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 268 to 317 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
1.19207	up	Nuclear RNA export factor 2 (TAP-like protein 2) (TAPL-2). [Uniprot/SWISSPROT;Acc:Q9GZY0]	cellular component	cytoplasm
				intracellular
				nuclear RNA export factor complex
				nucleus
			molecular function	nucleotide binding
				protein binding
				RNA binding
1.19212	down	Thyroglobulin precursor. [Uniprot/SWISSPROT;Acc:P01266]	biological process	hormone biosynthetic process
				signal transduction
				thyroid hormone generation
			cellular component	extracellular region
			molecular function	hormone activity
1.19496	up	Isocitrate dehydrogenase [NADP] cytoplasmic (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP). [Uniprot/SWISSPROT;Acc:O75874]	biological process	carbohydrate metabolic process
				glutathione metabolic process
				glyoxylate cycle
				isocitrate metabolic process
				metabolic process
				response to oxidative stress
				tricarboxylic acid cycle
			cellular component	cytoplasm
				cytosol
				peroxisome
			molecular function	isocitrate dehydrogenase (NADP+) activity
				magnesium ion binding
				manganese ion binding
				oxidoreductase activity
				oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
1.19539		Cysteine desulfurase, mitochondrial precursor (EC 2.8.1.7). [Uniprot/SWISSPROT;Acc:Q9Y697]	biological process	amino acid metabolic process
				metabolic process
				protein complex assembly
				sulfur amino acid metabolic process
			cellular component	cytoplasm
				cytosol
				mitochondrion
				nucleus
			molecular function	catalytic activity
				cysteine desulfurase activity
				lyase activity
				pyridoxal phosphate binding
				transaminase activity
				transferase activity
1.19545		Deoxyribonuclease-2-alpha precursor (EC 3.1.22.1) (Deoxyribonuclease II alpha) (DNase II alpha) (Acid DNase) (Lysosomal DNase II) (R31240_2). [Uniprot/SWISSPROT;Acc:O00115]	biological process	apoptosis
				DNA catabolic process
				DNA metabolic process
				erythrocyte differentiation
				multicellular organismal development
			cellular component	extracellular region
				lysosome
			molecular function	deoxyribonuclease II activity
				DNA binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.