MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Gene Ontology	Regulation	Accession	description	Minimum Ratio	Ratio	Class	Gene	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2619 to 2667 of 2667 in total

Gene Ontology	Regulation	description	Ratio	Class
voltage-gated ion channel activity	up	Potassium voltage-gated channel subfamily KQT member 4 (Voltage-gated potassium channel subunit Kv7.4) (Potassium channel subunit alpha KvLQT4) (KQT-like 4). [Uniprot/SWISSPROT;Acc:P56696]	1.17879	molecular function
		Voltage-dependent calcium channel gamma-7 subunit (Neuronal voltage- gated calcium channel gamma-7 subunit). [Uniprot/SWISSPROT;Acc:P62955]	3.41415
voltage-gated potassium channel activity		BTB/POZ domain-containing protein KCTD8. [Uniprot/SWISSPROT;Acc:Q6ZWB6]	1.73291
		Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (HPCN3) (HGK5) (HuKIII) (HLK3). [Uniprot/SWISSPROT;Acc:P22001]	4.67988
		Potassium voltage-gated channel subfamily KQT member 4 (Voltage-gated potassium channel subunit Kv7.4) (Potassium channel subunit alpha KvLQT4) (KQT-like 4). [Uniprot/SWISSPROT;Acc:P56696]	1.17879
voltage-gated potassium channel complex		BTB/POZ domain-containing protein KCTD8. [Uniprot/SWISSPROT;Acc:Q6ZWB6]	1.73291	cellular component
		Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (HPCN3) (HGK5) (HuKIII) (HLK3). [Uniprot/SWISSPROT;Acc:P22001]	4.67988
		Potassium voltage-gated channel subfamily KQT member 4 (Voltage-gated potassium channel subunit Kv7.4) (Potassium channel subunit alpha KvLQT4) (KQT-like 4). [Uniprot/SWISSPROT;Acc:P56696]	1.17879
Wnt receptor signaling pathway		Kremen protein 1 precursor (Kringle-containing protein marking the eye and the nose) (Kringle domain-containing transmembrane protein 1) (Dickkopf receptor). [Uniprot/SWISSPROT;Acc:Q96MU8]	3.89584	biological process
Z disc	down	Junctophilin-1 (Junctophilin type 1) (JP-1). [Uniprot/SWISSPROT;Acc:Q9HDC5]	3.39764	cellular component
zinc ion binding		ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha). [Uniprot/SWISSPROT;Acc:O43184]	1.76994	molecular function
		ADAM metallopeptidase with thrombospondin type 1 motif, 7 preproprotein [RefSeq_peptide;Acc:NP_055087]	1.28805
		Carboxypeptidase A2 precursor (EC 3.4.17.15). [Uniprot/SWISSPROT;Acc:P48052]	1.43351
		Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein). [Uniprot/SWISSPROT;Acc:Q8WZ64]	1.23783
		E3 ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein) (RING finger protein 196). [Uniprot/SWISSPROT;Acc:Q96EP1]	1.30869
		leukocyte-derived arginine aminopeptidase [RefSeq_peptide;Acc:NP_071745]	1.76583
		Myelin transcription factor 1-like protein (MyT1L protein) (MyT1-L). [Uniprot/SWISSPROT;Acc:Q9UL68]	2.58329
		Nuclear pore complex protein Nup153 (Nucleoporin Nup153) (153 kDa nucleoporin). [Uniprot/SWISSPROT;Acc:P49790]	1.48389
		Nuclear receptor ROR-alpha (Retinoid-related orphan receptor-alpha) (Nuclear receptor RZR-alpha). [Uniprot/SWISSPROT;Acc:P35398]	1.98137
		Proprotein convertase subtilisin/kexin type 6 precursor (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin/kexin-like protease PACE4) (Subtilisin-like proprotein convertase 4) (SPC4). [Uniprot/SWISSPROT;Acc:P29122]	1.19134
		Protein Jade-1 (PHD finger protein 17). [Uniprot/SWISSPROT;Acc:Q6IE81]	6.3909
		RING finger protein 170 (Putative LAG1-interacting protein). [Uniprot/SWISSPROT;Acc:Q96K19]	5.61927
		TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF). [Uniprot/SWISSPROT;Acc:Q92844]	2.93895
		Transcription factor GATA-6 (GATA-binding factor 6). [Uniprot/SWISSPROT;Acc:Q92908]	3.29064
		Tripartite motif-containing protein 58 (Protein BIA2). [Uniprot/SWISSPROT;Acc:Q8NG06]	1.31489
		Zinc finger and SCAN domain-containing protein 4 (Zinc finger protein 494). [Uniprot/SWISSPROT;Acc:Q8NAM6]	1.86204
		Zinc finger protein 202 (Zinc finger protein with KRAB and SCAN domains 10). [Uniprot/SWISSPROT;Acc:O95125]	1.89168
		Zinc finger protein basonuclin-2. [Uniprot/SWISSPROT;Acc:Q6ZN30]	1.1243
		Zinc finger protein OZF (Only zinc finger protein) (Zinc finger protein 146). [Uniprot/SWISSPROT;Acc:Q15072]	1.25113
	up	ADAM 22 precursor (A disintegrin and metalloproteinase domain 22) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) (Metalloproteinase-disintegrin ADAM22-3). [Uniprot/SWISSPROT;Acc:Q9P0K1]	1.16499
		ADAMTS-19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 19) (ADAM-TS 19) (ADAM-TS19). [Uniprot/SWISSPROT;Acc:Q8TE59]	2.45875
		Ataxin-7 (Spinocerebellar ataxia type 7 protein). [Uniprot/SWISSPROT;Acc:O15265]	2.29381
		Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta). [Uniprot/SWISSPROT;Acc:Q14839]	1.78439
		Forkhead box protein P2 (CAG repeat protein 44) (Trinucleotide repeat- containing gene 10 protein). [Uniprot/SWISSPROT;Acc:O15409]	1.57088
		Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1). [Uniprot/SWISSPROT;Acc:Q9UIS9]	1.22576
		OMA1 homolog, zinc metallopeptidase [RefSeq_peptide;Acc:NP_660286]	2.4954
		PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein). [Uniprot/SWISSPROT;Acc:Q96JY6]	5.81102
		Protein odd-skipped-related 2. [Uniprot/SWISSPROT;Acc:Q8N2R0]	4.14054
		RNA-binding protein 4 (RNA-binding motif protein 4) (RNA-binding motif protein 4a) (Lark homolog) (hLark). [Uniprot/SWISSPROT;Acc:Q9BWF3]	1.42264
		TCDD-inducible poly [ADP-ribose] polymerase (EC 2.4.2.30) (Poly [ADP- ribose] polymerase 7) (PARP-7). [Uniprot/SWISSPROT;Acc:Q7Z3E1]	1.66679
		U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20). [Uniprot/SWISSPROT;Acc:Q15696]	1.07618
		Zinc finger protein 219. [Uniprot/SWISSPROT;Acc:Q9P2Y4]	1.13007
		Zinc finger protein 384 (Nuclear matrix transcription factor 4) (Nuclear matrix protein 4) (CAG repeat protein 1) (CAS-interacting zinc finger protein) (Trinucleotide repeat-containing gene 1 protein). [Uniprot/SWISSPROT;Acc:Q8TF68]	1.59188
		Zinc finger protein ubi-d4 (Requiem) (Apoptosis response zinc finger protein) (D4, zinc and double PHD fingers family 2). [Uniprot/SWISSPROT;Acc:Q92785]	1.93995
		Zinc finger SWIM domain-containing protein 3. [Uniprot/SWISSPROT;Acc:Q96MP5]	1.56335
		zinc finger, FYVE domain containing 26 [RefSeq_peptide;Acc:NP_056161]	4.87049
zinc ion transport		zinc transporter like 2 [RefSeq_peptide;Acc:NP_598003]	2.45764	biological process
zinc ion transporter activity				molecular function
zygotic determination of anterior/posterior axis, embryo	down	Proprotein convertase subtilisin/kexin type 6 precursor (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin/kexin-like protease PACE4) (Subtilisin-like proprotein convertase 4) (SPC4). [Uniprot/SWISSPROT;Acc:P29122]	1.19134	biological process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.