MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	Gene Ontology	Accession	description	Class	Minimum Ratio	Gene	Maximum Ratio

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Showing element 2619 to 2667 of 2667 in total

Regulation  : up

Ratio	Gene Ontology	description	Class
5.19755	identical protein binding	Adiponectin receptor protein 1 (Progestin and adipoQ receptor family member I). [Uniprot/SWISSPROT;Acc:Q96A54]	molecular function
	integral to membrane		cellular component
	lipid metabolic process		biological process
	membrane		cellular component
	protein heterodimerization activity		molecular function
	receptor activity
5.31521	GTP binding	Rho-related BTB domain-containing protein 1. [Uniprot/SWISSPROT;Acc:O94844]
	intracellular		cellular component
	nucleotide binding		molecular function
	protein binding
	protein transport		biological process
	small GTPase mediated signal transduction
5.53059	GTP binding	rab and DnaJ domain containing [RefSeq_peptide;Acc:NP_057628]	molecular function
	GTPase activity
	heat shock protein binding
	intracellular		cellular component
	intracellular protein transport		biological process
	nucleocytoplasmic transport
	nucleotide binding		molecular function
	protein binding
	protein transport		biological process
	signal transduction
	small GTPase mediated signal transduction
5.81102	cell surface	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein). [Uniprot/SWISSPROT;Acc:Q96JY6]	cellular component
	cytoplasm
	cytoskeleton
	metal ion binding		molecular function
	nucleus		cellular component
	protein binding		molecular function
	zinc ion binding
6.50865	ATP binding	Serine/threonine-protein kinase Nek10 (EC 2.7.11.1) (NimA-related protein kinase 10). [Uniprot/SWISSPROT;Acc:Q6ZWH5]
	magnesium ion binding
	nucleotide binding
	protein amino acid phosphorylation		biological process
	protein kinase activity		molecular function
	protein serine/threonine kinase activity
	protein-tyrosine kinase activity
	transferase activity
7.27043	lipid binding	Short palate, lung and nasal epithelium carcinoma-associated protein 3 precursor. [Uniprot/SWISSPROT;Acc:Q9BQP9]
8.21788	catalytic activity	Ubiquitin-activating enzyme E1 domain-containing protein 1 (UFM1- activating enzyme) (Ubiquitin-activating enzyme 5) (ThiFP1). [Uniprot/SWISSPROT;Acc:Q9GZZ9]
	cofactor binding
	cytoplasm		cellular component
	defense response		biological process
	DNA binding		molecular function
	humoral immune response		biological process
	nucleus		cellular component
	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor		molecular function
	translation regulator activity
	ubiquitin cycle		biological process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.