MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	Gene Ontology	description	Class	Gene	Minimum Ratio	Maximum Ratio	Accession

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Showing element 243 to 292 of 2667 in total

Regulation  : down

Ratio	Gene Ontology	description	Class
1.27461	anatomical structure morphogenesis	Homeobox protein Hox-D3 (Hox-4A). [Uniprot/SWISSPROT;Acc:P31249]	biological process
	DNA binding		molecular function
	G-protein coupled receptor protein signaling pathway		biological process
	galanin receptor activity		molecular function
	integral to membrane		cellular component
	multicellular organismal development		biological process
	nucleus		cellular component
	regulation of transcription, DNA-dependent		biological process
	sequence-specific DNA binding		molecular function
	thyroid gland development		biological process
	transcription factor activity		molecular function
1.27696	cell cycle	Speedy protein A (Speedy-1) (Spy1) (Rapid inducer of G2/M progression in oocytes A) (RINGO A) (hSpy/Ringo A). [Uniprot/SWISSPROT;Acc:Q5MJ70]	biological process
	G1/S transition of mitotic cell cycle
	multicellular organismal development
	nucleus		cellular component
	positive regulation of cell proliferation		biological process
	positive regulation of cyclin-dependent protein kinase activity
	protein amino acid dephosphorylation
	protein binding		molecular function
	protein kinase binding
	protein phosphatase type 1 activity
	regulation of progression through cell cycle		biological process
	response to DNA damage stimulus
1.27802	homoiothermy	Melanoma-associated antigen B2 (MAGE-B2 antigen) (DSS-AHC critical interval MAGE superfamily 6) (DAM6) (MAGE XP-2). [Uniprot/SWISSPROT;Acc:O15479]
	ice binding		molecular function
	protein binding
	response to freezing		biological process
1.28356	cardiac muscle development	T-box transcription factor TBX2 (T-box protein 2). [Uniprot/SWISSPROT;Acc:Q13207]
	cell aging
	heart morphogenesis
	homoiothermy
	ice binding		molecular function
	mammary gland development		biological process
	membrane		cellular component
	multicellular organismal development		biological process
	muscle cell fate determination
	negative regulation of transcription from RNA polymerase II promoter
	nucleoside transporter activity		molecular function
	nucleus		cellular component
	positive regulation of cell proliferation		biological process
	protein binding		molecular function
	regulation of transcription, DNA-dependent		biological process
	response to freezing
	sequence-specific DNA binding		molecular function
	transcription		biological process
	transcription factor activity		molecular function
	transcription factor complex		cellular component
	transcriptional repressor activity		molecular function
	transport		biological process
1.28805	extracellular matrix	ADAM metallopeptidase with thrombospondin type 1 motif, 7 preproprotein [RefSeq_peptide;Acc:NP_055087]	cellular component

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.