MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Gene Ontology	Class	Minimum Ratio	Gene	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2569 to 2618 of 2667 in total

Ratio	Regulation	description	Gene Ontology	Class
5.31521	up	Rho-related BTB domain-containing protein 1. [Uniprot/SWISSPROT;Acc:O94844]	small GTPase mediated signal transduction	biological process
5.32612	down	Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (T cell transcription factor NFAT4) (NF-AT4) (NFATx). [Uniprot/SWISSPROT;Acc:Q12968]	cellular respiration
			cytoplasm	cellular component
			heart development	biological process
			inflammatory response
			nucleus	cellular component
			protein binding	molecular function
			regulation of transcription	biological process
			regulation of transcription from RNA polymerase II promoter
			regulation of transcription, DNA-dependent
			transcription coactivator activity	molecular function
			transcription factor activity
5.53059	up	rab and DnaJ domain containing [RefSeq_peptide;Acc:NP_057628]	GTP binding
			GTPase activity
			heat shock protein binding
			intracellular	cellular component
			intracellular protein transport	biological process
			nucleocytoplasmic transport
			nucleotide binding	molecular function
			protein binding
			protein transport	biological process
			signal transduction
			small GTPase mediated signal transduction
5.61927	down	RING finger protein 170 (Putative LAG1-interacting protein). [Uniprot/SWISSPROT;Acc:Q96K19]	integral to membrane	cellular component
			membrane
			metal ion binding	molecular function
			nucleoside transporter activity
			protein binding
			transport	biological process
			zinc ion binding	molecular function
5.81102	up	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein). [Uniprot/SWISSPROT;Acc:Q96JY6]	cell surface	cellular component
			cytoplasm
			cytoskeleton
			metal ion binding	molecular function
			nucleus	cellular component
			protein binding	molecular function
			zinc ion binding
5.83544	down	Nucleoplasmin-2. [Uniprot/SWISSPROT;Acc:Q86SE8]	chromatin remodeling	biological process
			cytoplasmic chromatin	cellular component
			embryonic development	biological process
			histone binding	molecular function
			nuclear chromatin	cellular component
			nucleic acid binding	molecular function
			nucleus	cellular component
			oocyte differentiation	biological process
			positive regulation of meiosis
			regulation of exit from mitosis
			single fertilization
5.84607		Tubulin-specific chaperone E (Tubulin-folding cofactor E). [Uniprot/SWISSPROT;Acc:Q15813]	axonogenesis
			beta-tubulin folding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.