MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Accession	Gene Ontology	Regulation	Minimum Ratio	description	Gene	Class	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2569 to 2618 of 2667 in total

Ratio	Gene Ontology	Regulation	description	Class
5.31521	small GTPase mediated signal transduction	up	Rho-related BTB domain-containing protein 1. [Uniprot/SWISSPROT;Acc:O94844]	biological process
5.32612	cellular respiration	down	Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (T cell transcription factor NFAT4) (NF-AT4) (NFATx). [Uniprot/SWISSPROT;Acc:Q12968]
	cytoplasm			cellular component
	heart development			biological process
	inflammatory response
	nucleus			cellular component
	protein binding			molecular function
	regulation of transcription			biological process
	regulation of transcription from RNA polymerase II promoter
	regulation of transcription, DNA-dependent
	transcription coactivator activity			molecular function
	transcription factor activity
5.53059	GTP binding	up	rab and DnaJ domain containing [RefSeq_peptide;Acc:NP_057628]
	GTPase activity
	heat shock protein binding
	intracellular			cellular component
	intracellular protein transport			biological process
	nucleocytoplasmic transport
	nucleotide binding			molecular function
	protein binding
	protein transport			biological process
	signal transduction
	small GTPase mediated signal transduction
5.61927	integral to membrane	down	RING finger protein 170 (Putative LAG1-interacting protein). [Uniprot/SWISSPROT;Acc:Q96K19]	cellular component
	membrane
	metal ion binding			molecular function
	nucleoside transporter activity
	protein binding
	transport			biological process
	zinc ion binding			molecular function
5.81102	cell surface	up	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein). [Uniprot/SWISSPROT;Acc:Q96JY6]	cellular component
	cytoplasm
	cytoskeleton
	metal ion binding			molecular function
	nucleus			cellular component
	protein binding			molecular function
	zinc ion binding
5.83544	chromatin remodeling	down	Nucleoplasmin-2. [Uniprot/SWISSPROT;Acc:Q86SE8]	biological process
	cytoplasmic chromatin			cellular component
	embryonic development			biological process
	histone binding			molecular function
	nuclear chromatin			cellular component
	nucleic acid binding			molecular function
	nucleus			cellular component
	oocyte differentiation			biological process
	positive regulation of meiosis
	regulation of exit from mitosis
	single fertilization
5.84607	axonogenesis		Tubulin-specific chaperone E (Tubulin-folding cofactor E). [Uniprot/SWISSPROT;Acc:Q15813]
	beta-tubulin folding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.