MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Accession	Gene Ontology	Class	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2569 to 2618 of 2667 in total

Regulation  : up

Ratio	description	Gene Ontology	Class
4.40598	GMP reductase 1 (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase 1) (Guanosine monophosphate reductase 1). [Uniprot/SWISSPROT;Acc:P36959]	metabolic process	biological process
		metal ion binding	molecular function
		nucleotide metabolic process	biological process
		oxidoreductase activity	molecular function
		potassium ion binding
		response to cold	biological process
4.55177	Transcription factor SOX-14. [Uniprot/SWISSPROT;Acc:O95416]	chromatin	cellular component
		DNA binding	molecular function
		establishment and/or maintenance of chromatin architecture	biological process
		nervous system development
		nucleus	cellular component
		regulation of transcription, DNA-dependent	biological process
		transcription
		transcription factor activity	molecular function
4.55371	Parathyroid hormone/parathyroid hormone-related peptide receptor precursor (PTH/PTHr receptor) (PTH/PTHrP type I receptor). [Uniprot/SWISSPROT;Acc:Q03431]	cytoplasm	cellular component
		G-protein coupled receptor activity	molecular function
		G-protein signaling, coupled to cyclic nucleotide second messenger	biological process
		integral to membrane	cellular component
		integral to plasma membrane
		membrane
		nucleus
		parathyroid hormone receptor activity	molecular function
		receptor activity
		signal transduction	biological process
		skeletal development
4.67988	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (HPCN3) (HGK5) (HuKIII) (HLK3). [Uniprot/SWISSPROT;Acc:P22001]	delayed rectifier potassium channel activity	molecular function
		dicarboxylic acid transport	biological process
		integral to membrane	cellular component
		ion channel activity	molecular function
		ion transport	biological process
		membrane	cellular component
		membrane fraction
		outward rectifier potassium channel activity	molecular function
		potassium ion binding
		potassium ion transport	biological process
		protein binding	molecular function
		sodium:dicarboxylate symporter activity
		voltage-gated ion channel activity
		voltage-gated potassium channel activity
		voltage-gated potassium channel complex	cellular component
4.87049	zinc finger, FYVE domain containing 26 [RefSeq_peptide;Acc:NP_056161]	intracellular
		metal ion binding	molecular function
		nucleic acid binding
		zinc ion binding
5.01332	Ufm1-specific protease 2 (EC 3.4.22.-) (UfSP2). [Uniprot/SWISSPROT;Acc:Q9NUQ7]	cysteine-type peptidase activity
		thiolester hydrolase activity
		ubiquitin cycle	biological process
5.19755	Adiponectin receptor protein 1 (Progestin and adipoQ receptor family member I). [Uniprot/SWISSPROT;Acc:Q96A54]	fatty acid oxidation
		hormone binding	molecular function
		hormone-mediated signaling	biological process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.