MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2519 to 2568 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
4.67988	up	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (HPCN3) (HGK5) (HuKIII) (HLK3). [Uniprot/SWISSPROT;Acc:P22001]	molecular function	sodium:dicarboxylate symporter activity
				voltage-gated ion channel activity
				voltage-gated potassium channel activity
4.69231	down	Arylamine N-acetyltransferase 2 (EC 2.3.1.5) (Arylamide acetylase 2) (Polymorphic arylamine N-acetyltransferase) (PNAT) (N- acetyltransferase type 2) (NAT-2). [Uniprot/SWISSPROT;Acc:P11245]	biological process	metabolic process
			cellular component	cytoplasm
			molecular function	acetyltransferase activity
				arylamine N-acetyltransferase activity
				transferase activity
4.71132		Pyruvate kinase isozymes R/L (EC 2.7.1.40) (R-type/L-type pyruvate kinase) (Red cell/liver pyruvate kinase) (Pyruvate kinase 1). [Uniprot/SWISSPROT;Acc:P30613]	biological process	glycolysis
				response to other organism
			cellular component	cellular_component
			molecular function	magnesium ion binding
				potassium ion binding
				pyruvate kinase activity
				transferase activity
4.87049	up	zinc finger, FYVE domain containing 26 [RefSeq_peptide;Acc:NP_056161]	cellular component	intracellular
			molecular function	metal ion binding
				nucleic acid binding
				zinc ion binding
4.90535	down	DAZ-associated protein 2 (Deleted in azoospermia-associated protein 2). [Uniprot/SWISSPROT;Acc:Q15038]		protein binding
4.93372		Ankyrin repeat and SOCS box protein 12 (ASB-12). [Uniprot/SWISSPROT;Acc:Q8WXK4]	biological process	intracellular signaling cascade
5.01332	up	Ufm1-specific protease 2 (EC 3.4.22.-) (UfSP2). [Uniprot/SWISSPROT;Acc:Q9NUQ7]		ubiquitin cycle
			molecular function	cysteine-type peptidase activity
				thiolester hydrolase activity
5.19755		Adiponectin receptor protein 1 (Progestin and adipoQ receptor family member I). [Uniprot/SWISSPROT;Acc:Q96A54]	biological process	fatty acid oxidation
				hormone-mediated signaling
				lipid metabolic process
			cellular component	integral to membrane
				membrane
			molecular function	hormone binding
				identical protein binding
				protein heterodimerization activity
				receptor activity
5.23046	down	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K). [Uniprot/SWISSPROT;Acc:P48736]	biological process	G-protein coupled receptor protein signaling pathway
				negative regulation of apoptosis
				phosphoinositide phosphorylation
				phosphoinositide-mediated signaling
				protein amino acid phosphorylation
			cellular component	phosphoinositide 3-kinase complex
			molecular function	1-phosphatidylinositol-3-kinase activity
				inositol or phosphatidylinositol kinase activity
				phosphatidylinositol-4,5-bisphosphate 3-kinase activity
				phosphotransferase activity, alcohol group as acceptor
				protein binding
				transferase activity
5.31521	up	Rho-related BTB domain-containing protein 1. [Uniprot/SWISSPROT;Acc:O94844]	biological process	protein transport
				small GTPase mediated signal transduction
			cellular component	intracellular
			molecular function	GTP binding
				nucleotide binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.