MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Minimum Ratio	Class	Gene Ontology	Accession	Gene	Maximum Ratio

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Showing element 2519 to 2568 of 2667 in total

Regulation  : up

Ratio	description	Class	Gene Ontology
4.03725	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon). [Uniprot/SWISSPROT;Acc:P23469]	molecular function	transmembrane receptor protein tyrosine phosphatase activity
4.04651	Sad1/unc-84-like protein 2 (Rab5-interacting protein) (Rab5IP). [Uniprot/SWISSPROT;Acc:Q9UH99]	biological process	mitotic spindle organization and biogenesis
			nuclear membrane organization and biogenesis
			nuclear migration
			regulation of transcription, DNA-dependent
		cellular component	condensed nuclear chromosome
			endosome
			integral to membrane
			membrane
			nuclear chromosome, telomeric region
			nuclear envelope
			nucleus
		molecular function	microtubule binding
			protein binding
			protein dimerization activity
			sequence-specific DNA binding
			transcription factor activity
4.05743	Clarin-1 (Usher syndrome type-3 protein). [Uniprot/SWISSPROT;Acc:P58418]	biological process	response to stimulus
			sensory perception of sound
			visual perception
		cellular component	integral to membrane
			membrane
4.07995	AP-3 complex subunit sigma-1 (Adapter-related protein complex 3 sigma- 1 subunit) (Sigma-adaptin 3a) (AP-3 complex sigma-3A subunit) (Sigma- 3A-adaptin) (Clathrin-associated/assembly/adapter protein, small 3). [Uniprot/SWISSPROT;Acc:Q92572]	biological process	insulin receptor signaling pathway
			intracellular protein transport
			protein complex assembly
			transport
			vesicle-mediated transport
		cellular component	cytoplasmic vesicle
			Golgi apparatus
			membrane
			membrane coat
			membrane coat adaptor complex
			transport vesicle
		molecular function	protein binding
			protein transporter activity
			transporter activity
4.1026	Uncharacterized protein C2orf29. [Uniprot/SWISSPROT;Acc:Q9UKZ1]	biological process	cell proliferation
		cellular component	cellular_component
		molecular function	molecular_function
4.14054	Protein odd-skipped-related 2. [Uniprot/SWISSPROT;Acc:Q8N2R0]	biological process	embryonic skeletal morphogenesis
			positive regulation of cell proliferation
		cellular component	intracellular
			nucleus
		molecular function	metal ion binding
			nucleic acid binding
			zinc ion binding
4.22898	Enoyl-CoA hydratase domain-containing protein 1. [Uniprot/SWISSPROT;Acc:Q9NTX5]	biological process	metabolic process
		molecular function	catalytic activity
4.40598	GMP reductase 1 (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase 1) (Guanosine monophosphate reductase 1). [Uniprot/SWISSPROT;Acc:P36959]	biological process	metabolic process
			nucleotide metabolic process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.