MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Accession	Ratio	Gene Ontology	Regulation	Minimum Ratio	description	Class	Gene	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2501 to 2550 of 2667 in total

Ratio	Gene Ontology	Regulation	description	Class
4.62042	integral to membrane	down	Leukocyte antigen CD37 (Tetraspanin-26) (Tspan-26). [Uniprot/SWISSPROT;Acc:P11049]	cellular component
	integral to plasma membrane
	membrane
	plasma membrane
	protein amino acid N-linked glycosylation			biological process
	visual perception
4.67988	delayed rectifier potassium channel activity	up	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (HPCN3) (HGK5) (HuKIII) (HLK3). [Uniprot/SWISSPROT;Acc:P22001]	molecular function
	dicarboxylic acid transport			biological process
	integral to membrane			cellular component
	ion channel activity			molecular function
	ion transport			biological process
	membrane			cellular component
	membrane fraction
	outward rectifier potassium channel activity			molecular function
	potassium ion binding
	potassium ion transport			biological process
	protein binding			molecular function
	sodium:dicarboxylate symporter activity
	voltage-gated ion channel activity
	voltage-gated potassium channel activity
	voltage-gated potassium channel complex			cellular component
4.69231	acetyltransferase activity	down	Arylamine N-acetyltransferase 2 (EC 2.3.1.5) (Arylamide acetylase 2) (Polymorphic arylamine N-acetyltransferase) (PNAT) (N- acetyltransferase type 2) (NAT-2). [Uniprot/SWISSPROT;Acc:P11245]	molecular function
	arylamine N-acetyltransferase activity
	cytoplasm			cellular component
	metabolic process			biological process
	transferase activity			molecular function
4.71132	cellular_component		Pyruvate kinase isozymes R/L (EC 2.7.1.40) (R-type/L-type pyruvate kinase) (Red cell/liver pyruvate kinase) (Pyruvate kinase 1). [Uniprot/SWISSPROT;Acc:P30613]	cellular component
	glycolysis			biological process
	magnesium ion binding			molecular function
	potassium ion binding
	pyruvate kinase activity
	response to other organism			biological process
	transferase activity			molecular function
4.87049	intracellular	up	zinc finger, FYVE domain containing 26 [RefSeq_peptide;Acc:NP_056161]	cellular component
	metal ion binding			molecular function
	nucleic acid binding
	zinc ion binding
4.90535	protein binding	down	DAZ-associated protein 2 (Deleted in azoospermia-associated protein 2). [Uniprot/SWISSPROT;Acc:Q15038]
4.93372	intracellular signaling cascade		Ankyrin repeat and SOCS box protein 12 (ASB-12). [Uniprot/SWISSPROT;Acc:Q8WXK4]	biological process
5.01332	cysteine-type peptidase activity	up	Ufm1-specific protease 2 (EC 3.4.22.-) (UfSP2). [Uniprot/SWISSPROT;Acc:Q9NUQ7]	molecular function
	thiolester hydrolase activity
	ubiquitin cycle			biological process
5.19755	fatty acid oxidation		Adiponectin receptor protein 1 (Progestin and adipoQ receptor family member I). [Uniprot/SWISSPROT;Acc:Q96A54]
	hormone binding			molecular function
	hormone-mediated signaling			biological process
	identical protein binding			molecular function
	integral to membrane			cellular component
	lipid metabolic process			biological process
	membrane			cellular component
	protein heterodimerization activity			molecular function

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.