MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	Gene Ontology	description	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2469 to 2518 of 2667 in total

Ratio	Regulation	Gene Ontology	description	Class
4.49282	down	positive regulation of transcription from RNA polymerase II promoter	Enhancer of polycomb homolog 1. [Uniprot/SWISSPROT;Acc:Q9H2F5]	biological process
		regulation of cell growth
		regulation of transcription, DNA-dependent
		transcription
		transcriptional activator activity		molecular function
		transcriptional repressor activity
4.49844		extracellular space	Secretogranin-1 precursor (Secretogranin I) (SgI) (Chromogranin B) (CgB) [Contains: GAWK peptide; CCB peptide]. [Uniprot/SWISSPROT;Acc:P05060]	cellular component
		hormone activity		molecular function
4.50619		apoptosis	Engulfment and cell motility protein 2 (CED-12 homolog A) (hCED-12A). [Uniprot/SWISSPROT;Acc:Q96JJ3]	biological process
		cytoplasm		cellular component
		cytoskeleton
		membrane
		phagocytosis		biological process
4.55177	up	chromatin	Transcription factor SOX-14. [Uniprot/SWISSPROT;Acc:O95416]	cellular component
		DNA binding		molecular function
		establishment and/or maintenance of chromatin architecture		biological process
		nervous system development
		nucleus		cellular component
		regulation of transcription, DNA-dependent		biological process
		transcription
		transcription factor activity		molecular function
4.55371		cytoplasm	Parathyroid hormone/parathyroid hormone-related peptide receptor precursor (PTH/PTHr receptor) (PTH/PTHrP type I receptor). [Uniprot/SWISSPROT;Acc:Q03431]	cellular component
		G-protein coupled receptor activity		molecular function
		G-protein signaling, coupled to cyclic nucleotide second messenger		biological process
		integral to membrane		cellular component
		integral to plasma membrane
		membrane
		nucleus
		parathyroid hormone receptor activity		molecular function
		receptor activity
		signal transduction		biological process
		skeletal development
4.62042	down	integral to membrane	Leukocyte antigen CD37 (Tetraspanin-26) (Tspan-26). [Uniprot/SWISSPROT;Acc:P11049]	cellular component
		integral to plasma membrane
		membrane
		plasma membrane
		protein amino acid N-linked glycosylation		biological process
		visual perception
4.67988	up	delayed rectifier potassium channel activity	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (HPCN3) (HGK5) (HuKIII) (HLK3). [Uniprot/SWISSPROT;Acc:P22001]	molecular function
		dicarboxylic acid transport		biological process
		integral to membrane		cellular component
		ion channel activity		molecular function
		ion transport		biological process
		membrane		cellular component
		membrane fraction
		outward rectifier potassium channel activity		molecular function
		potassium ion binding
		potassium ion transport		biological process
		protein binding		molecular function
		sodium:dicarboxylate symporter activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.