MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	Gene Ontology	description	Class	Gene	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2469 to 2518 of 2667 in total

Regulation  : up

Ratio	Gene Ontology	description	Class
3.70292	homoiothermy	Homeobox protein SIX4 (Sine oculis homeobox homolog 4). [Uniprot/SWISSPROT;Acc:Q9UIU6]	biological process
	ice binding		molecular function
	inner ear morphogenesis		biological process
	multicellular organismal development
	myoblast migration
	nucleus		cellular component
	positive regulation of transcription		biological process
	regulation of transcription, DNA-dependent
	response to freezing
	sequence-specific DNA binding		molecular function
	striated muscle development		biological process
	thymus development
	transcription factor activity		molecular function
3.74971	glutathione peroxidase activity	Glutathione peroxidase 6 precursor (EC 1.11.1.9). [Uniprot/SWISSPROT;Acc:P59796]
	oxidoreductase activity
	response to oxidative stress		biological process
	selenium binding		molecular function
3.76904	integral to membrane	Progestin and adipoQ receptor family member 4 (Progestin and adipoQ receptor family member IV). [Uniprot/SWISSPROT;Acc:Q8N4S7]	cellular component
	membrane
	receptor activity		molecular function
3.81736	cell cycle	Transcription factor E2F3 (E2F-3). [Uniprot/SWISSPROT;Acc:O00716]	biological process
	homoiothermy
	ice binding		molecular function
	nucleus		cellular component
	protein binding		molecular function
	regulation of progression through cell cycle		biological process
	regulation of transcription, DNA-dependent
	response to freezing
	transcription
	transcription factor activity		molecular function
	transcription factor complex		cellular component
	transcription initiation from RNA polymerase II promoter		biological process
3.89584	cell communication	Kremen protein 1 precursor (Kringle-containing protein marking the eye and the nose) (Kringle domain-containing transmembrane protein 1) (Dickkopf receptor). [Uniprot/SWISSPROT;Acc:Q96MU8]
	integral to membrane		cellular component
	membrane
	membrane fraction
	molecular_function		molecular function
	Wnt receptor signaling pathway		biological process
4.03725	cytoplasm	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon). [Uniprot/SWISSPROT;Acc:P23469]	cellular component
	dephosphorylation		biological process
	hydrolase activity		molecular function
	integral to plasma membrane		cellular component
	membrane
	phosphoric monoester hydrolase activity		molecular function
	protein amino acid dephosphorylation		biological process
	protein homodimerization activity		molecular function
	protein tyrosine phosphatase activity
	receptor activity
	soluble fraction		cellular component
	transmembrane receptor protein tyrosine phosphatase activity		molecular function

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.