Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes


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Gene Ontology Accession Regulation Ratio Gene description Class Minimum Ratio Maximum Ratio
Results: HTML CSV LaTeX Showing element 2451 to 2500 of 2667 in total
Gene Ontology
Regulation
Ratio
description
Class
transcription cofactor activity up 1.16921 Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1). [Uniprot/SWISSPROT;Acc:Q96HZ4] molecular function
1.31661 Chloride anion exchanger (Protein DRA) (Down-regulated in adenoma) (Solute carrier family 26 member 3). [Uniprot/SWISSPROT;Acc:P40879]
transcription corepressor activity down 3.27919 Calsenilin (Kv channel-interacting protein 3) (KChIP3) (A-type potassium channel modulatory protein 3) (DRE-antagonist modulator) (DREAM). [Uniprot/SWISSPROT;Acc:Q9Y2W7]
up 1.22576 Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1). [Uniprot/SWISSPROT;Acc:Q9UIS9]
transcription factor activity down 1.27461 Homeobox protein Hox-D3 (Hox-4A). [Uniprot/SWISSPROT;Acc:P31249]
1.28356 T-box transcription factor TBX2 (T-box protein 2). [Uniprot/SWISSPROT;Acc:Q13207]
1.86204 Zinc finger and SCAN domain-containing protein 4 (Zinc finger protein 494). [Uniprot/SWISSPROT;Acc:Q8NAM6]
1.89168 Zinc finger protein 202 (Zinc finger protein with KRAB and SCAN domains 10). [Uniprot/SWISSPROT;Acc:O95125]
1.98137 Nuclear receptor ROR-alpha (Retinoid-related orphan receptor-alpha) (Nuclear receptor RZR-alpha). [Uniprot/SWISSPROT;Acc:P35398]
2.58329 Myelin transcription factor 1-like protein (MyT1L protein) (MyT1-L). [Uniprot/SWISSPROT;Acc:Q9UL68]
3.29064 Transcription factor GATA-6 (GATA-binding factor 6). [Uniprot/SWISSPROT;Acc:Q92908]
3.48313 Homeobox protein TGIF2 (5'-TG-3'-interacting factor 2) (TGFB-induced factor 2) (TGF(beta)-induced transcription factor 2). [Uniprot/SWISSPROT;Acc:Q9GZN2]
3.83977 AT-hook-containing transcription factor 1 (Embryonic large molecule derived from yolk sac). [Uniprot/SWISSPROT;Acc:Q8WYP5]
4.4149 X box-binding protein 1 (XBP-1) (Tax-responsive element-binding protein 5). [Uniprot/SWISSPROT;Acc:P17861]
5.32612 Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (T cell transcription factor NFAT4) (NF-AT4) (NFATx). [Uniprot/SWISSPROT;Acc:Q12968]
up 1.10889 Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR). [Uniprot/SWISSPROT;Acc:Q96F24]
1.13007 Zinc finger protein 219. [Uniprot/SWISSPROT;Acc:Q9P2Y4]
1.16921 Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1). [Uniprot/SWISSPROT;Acc:Q96HZ4]
1.22576 Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1). [Uniprot/SWISSPROT;Acc:Q9UIS9]
1.30407 Homeobox protein Nkx-2.8 (Homeobox protein NK-2 homolog H). [Uniprot/SWISSPROT;Acc:O15522]
1.31661 Chloride anion exchanger (Protein DRA) (Down-regulated in adenoma) (Solute carrier family 26 member 3). [Uniprot/SWISSPROT;Acc:P40879]
1.33465 T-box transcription factor TBX5 (T-box protein 5). [Uniprot/SWISSPROT;Acc:Q99593]
1.45624 Transcription factor NF-E2 45 kDa subunit (Nuclear factor, erythroid- derived 2 45 kDa subunit) (p45 NF-E2) (Leucine zipper protein NF-E2). [Uniprot/SWISSPROT;Acc:Q16621]
1.50206 LAG1 longevity assurance homolog 4. [Uniprot/SWISSPROT;Acc:Q9HA82]
1.57088 Forkhead box protein P2 (CAG repeat protein 44) (Trinucleotide repeat- containing gene 10 protein). [Uniprot/SWISSPROT;Acc:O15409]
1.69345 GC-rich sequence DNA-binding factor (GCF) (Transcription factor 9) (TCF-9). [Uniprot/SWISSPROT;Acc:P16383]
2.10428 Transcription factor AP-1 (Activator protein 1) (AP1) (Proto-oncogene c-jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39). [Uniprot/SWISSPROT;Acc:P05412]
2.86298 T-brain-1 protein (T-box brain protein 1) (TBR-1) (TES-56). [Uniprot/SWISSPROT;Acc:Q16650]
3.70292 Homeobox protein SIX4 (Sine oculis homeobox homolog 4). [Uniprot/SWISSPROT;Acc:Q9UIU6]
3.81736 Transcription factor E2F3 (E2F-3). [Uniprot/SWISSPROT;Acc:O00716]
4.04651 Sad1/unc-84-like protein 2 (Rab5-interacting protein) (Rab5IP). [Uniprot/SWISSPROT;Acc:Q9UH99]
4.55177 Transcription factor SOX-14. [Uniprot/SWISSPROT;Acc:O95416]
transcription factor binding down 1.21384 Disco-interacting protein 2 homolog C. [Uniprot/SWISSPROT;Acc:Q9Y2E4]
up 1.78439 Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta). [Uniprot/SWISSPROT;Acc:Q14839]
transcription factor complex down 1.28356 T-box transcription factor TBX2 (T-box protein 2). [Uniprot/SWISSPROT;Acc:Q13207] cellular component
up 1.16921 Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1). [Uniprot/SWISSPROT;Acc:Q96HZ4]
2.10428 Transcription factor AP-1 (Activator protein 1) (AP1) (Proto-oncogene c-jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39). [Uniprot/SWISSPROT;Acc:P05412]
3.81736 Transcription factor E2F3 (E2F-3). [Uniprot/SWISSPROT;Acc:O00716]
transcription from RNA polymerase II promoter 1.22576 Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1). [Uniprot/SWISSPROT;Acc:Q9UIS9] biological process
1.30407 Homeobox protein Nkx-2.8 (Homeobox protein NK-2 homolog H). [Uniprot/SWISSPROT;Acc:O15522]
1.44789 POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (OCT-binding factor 1) (BOB-1) (OCA-B). [Uniprot/SWISSPROT;Acc:Q16633]
transcription from RNA polymerase III promoter down 6.56408 DNA-directed RNA polymerase III subunit RPC8 (RNA polymerase III subunit C8) (DNA-directed RNA polymerase III subunit H) (DNA-directed RNA polymerase III subunit 22.9 kDa polypeptide). [Uniprot/SWISSPROT;Acc:Q9Y535]
transcription initiation from RNA polymerase II promoter up 3.81736 Transcription factor E2F3 (E2F-3). [Uniprot/SWISSPROT;Acc:O00716]
transcription regulator activity down 1.30082 CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2). [Uniprot/SWISSPROT;Acc:Q9NZN8] molecular function
up 1.16921 Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1). [Uniprot/SWISSPROT;Acc:Q96HZ4]
transcriptional activator activity down 2.83611 SERTA domain-containing protein 3 (Replication protein-binding trans- activator) (RPA-binding trans-activator). [Uniprot/SWISSPROT;Acc:Q9UJW9]
3.29064 Transcription factor GATA-6 (GATA-binding factor 6). [Uniprot/SWISSPROT;Acc:Q92908]
4.49282 Enhancer of polycomb homolog 1. [Uniprot/SWISSPROT;Acc:Q9H2F5]
up 1.25147 T-lymphocyte activation antigen CD86 precursor (Activation B7-2 antigen) (CTLA-4 counter-receptor B7.2) (B70) (FUN-1) (BU63). [Uniprot/SWISSPROT;Acc:P42081]
1.33465 T-box transcription factor TBX5 (T-box protein 5). [Uniprot/SWISSPROT;Acc:Q99593]

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- http://analysis.yellowcouch.org/