MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Ratio	Regulation	description	Gene Ontology	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2451 to 2500 of 2667 in total

Ratio	Regulation	description	Gene Ontology	Class
4.40797	down	Aldehyde dehydrogenase, mitochondrial precursor (EC 1.2.1.3) (ALDH class 2) (ALDHI) (ALDH-E2). [Uniprot/SWISSPROT;Acc:P05091]	neuropeptide hormone activity	molecular function
			neuropeptide signaling pathway	biological process
			oxidoreductase activity	molecular function
4.4149		X box-binding protein 1 (XBP-1) (Tax-responsive element-binding protein 5). [Uniprot/SWISSPROT;Acc:P17861]	DNA binding
			immune response	biological process
			nucleus	cellular component
			protein dimerization activity	molecular function
			regulation of transcription	biological process
			regulation of transcription, DNA-dependent
			sequence-specific DNA binding	molecular function
			transcription	biological process
			transcription factor activity	molecular function
4.49282		Enhancer of polycomb homolog 1. [Uniprot/SWISSPROT;Acc:Q9H2F5]	chromatin modification	biological process
			negative regulation of gene expression, epigenetic
			negative regulation of transcription from RNA polymerase II promoter
			nuclear membrane	cellular component
			nucleoplasm
			nucleus
			positive regulation of transcription from RNA polymerase II promoter	biological process
			regulation of cell growth
			regulation of transcription, DNA-dependent
			transcription
			transcriptional activator activity	molecular function
			transcriptional repressor activity
4.49844		Secretogranin-1 precursor (Secretogranin I) (SgI) (Chromogranin B) (CgB) [Contains: GAWK peptide; CCB peptide]. [Uniprot/SWISSPROT;Acc:P05060]	extracellular space	cellular component
			hormone activity	molecular function
4.50619		Engulfment and cell motility protein 2 (CED-12 homolog A) (hCED-12A). [Uniprot/SWISSPROT;Acc:Q96JJ3]	apoptosis	biological process
			cytoplasm	cellular component
			cytoskeleton
			membrane
			phagocytosis	biological process
4.55177	up	Transcription factor SOX-14. [Uniprot/SWISSPROT;Acc:O95416]	chromatin	cellular component
			DNA binding	molecular function
			establishment and/or maintenance of chromatin architecture	biological process
			nervous system development
			nucleus	cellular component
			regulation of transcription, DNA-dependent	biological process
			transcription
			transcription factor activity	molecular function
4.55371		Parathyroid hormone/parathyroid hormone-related peptide receptor precursor (PTH/PTHr receptor) (PTH/PTHrP type I receptor). [Uniprot/SWISSPROT;Acc:Q03431]	cytoplasm	cellular component
			G-protein coupled receptor activity	molecular function
			G-protein signaling, coupled to cyclic nucleotide second messenger	biological process
			integral to membrane	cellular component
			integral to plasma membrane
			membrane
			nucleus
			parathyroid hormone receptor activity	molecular function
			receptor activity
			signal transduction	biological process
			skeletal development

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.