MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Gene Ontology	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2419 to 2468 of 2667 in total

Ratio	Regulation	description	Gene Ontology	Class
4.14054	up	Protein odd-skipped-related 2. [Uniprot/SWISSPROT;Acc:Q8N2R0]	embryonic skeletal morphogenesis	biological process
			intracellular	cellular component
			metal ion binding	molecular function
			nucleic acid binding
			nucleus	cellular component
			positive regulation of cell proliferation	biological process
			zinc ion binding	molecular function
4.14557	down	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3). [Uniprot/SWISSPROT;Acc:Q8IV63]	ATP binding
			nucleotide binding
			nucleus	cellular component
			protein amino acid phosphorylation	biological process
			protein kinase activity	molecular function
			protein serine/threonine kinase activity
			transferase activity
4.21401		Uncharacterized protein C17orf56. [Uniprot/SWISSPROT;Acc:Q96N21]	membrane	cellular component
4.22898	up	Enoyl-CoA hydratase domain-containing protein 1. [Uniprot/SWISSPROT;Acc:Q9NTX5]	catalytic activity	molecular function
			metabolic process	biological process
4.40598		GMP reductase 1 (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase 1) (Guanosine monophosphate reductase 1). [Uniprot/SWISSPROT;Acc:P36959]	catalytic activity	molecular function
			GMP reductase activity
			metabolic process	biological process
			metal ion binding	molecular function
			nucleotide metabolic process	biological process
			oxidoreductase activity	molecular function
			potassium ion binding
			response to cold	biological process
4.40797	down	Aldehyde dehydrogenase, mitochondrial precursor (EC 1.2.1.3) (ALDH class 2) (ALDHI) (ALDH-E2). [Uniprot/SWISSPROT;Acc:P05091]	alcohol metabolic process
			aldehyde dehydrogenase (NAD) activity	molecular function
			aldehyde dehydrogenase [NAD(P)+] activity
			carbohydrate metabolic process	biological process
			electron carrier activity	molecular function
			metabolic process	biological process
			mitochondrion	cellular component
			neuropeptide hormone activity	molecular function
			neuropeptide signaling pathway	biological process
			oxidoreductase activity	molecular function
4.4149		X box-binding protein 1 (XBP-1) (Tax-responsive element-binding protein 5). [Uniprot/SWISSPROT;Acc:P17861]	DNA binding
			immune response	biological process
			nucleus	cellular component
			protein dimerization activity	molecular function
			regulation of transcription	biological process
			regulation of transcription, DNA-dependent
			sequence-specific DNA binding	molecular function
			transcription	biological process
			transcription factor activity	molecular function
4.49282		Enhancer of polycomb homolog 1. [Uniprot/SWISSPROT;Acc:Q9H2F5]	chromatin modification	biological process
			negative regulation of gene expression, epigenetic
			negative regulation of transcription from RNA polymerase II promoter
			nuclear membrane	cellular component
			nucleoplasm
			nucleus

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.