MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	Gene Ontology	description	Accession	Class	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2401 to 2450 of 2667 in total

Regulation  : up

Ratio	Gene Ontology	description	Class
3.32356	sugar binding	Nuclear receptor-interacting protein 3 (Sarcoma antigen NY-SAR-105). [Uniprot/SWISSPROT;Acc:Q9NQ35]	molecular function
3.35536	calmodulin binding	RNA polymerase-associated protein RTF1 homolog. [Uniprot/SWISSPROT;Acc:Q92541]
	nucleolus		cellular component
	nucleus
	regulation of transcription, DNA-dependent		biological process
	transcription
3.36725	double-stranded RNA binding	TAR RNA-binding protein 2 (Trans-activation-responsive RNA-binding protein). [Uniprot/SWISSPROT;Acc:Q15633]	molecular function
	intracellular		cellular component
	negative regulation of antiviral response by host		biological process
	negative regulation of protein kinase activity
	nucleus		cellular component
	positive regulation of viral genome replication		biological process
	positive regulation of viral protein levels in host cell
	protein binding		molecular function
	protein heterodimerization activity
	regulation of transcription from RNA polymerase II promoter		biological process
	regulation of viral transcription
3.41415	calcium ion binding	Voltage-dependent calcium channel gamma-7 subunit (Neuronal voltage- gated calcium channel gamma-7 subunit). [Uniprot/SWISSPROT;Acc:P62955]	molecular function
	calcium ion transport		biological process
	integral to membrane		cellular component
	ion transport		biological process
	membrane		cellular component
	voltage-gated calcium channel activity		molecular function
	voltage-gated calcium channel complex		cellular component
	voltage-gated ion channel activity		molecular function
3.41794	protein binding	LRRC44 protein. [Uniprot/SPTREMBL;Acc:Q6P5P7]
3.48558	ATP binding	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2) (Tyrosine-protein kinase TYRO6). [Uniprot/SWISSPROT;Acc:P54753]
	axon guidance		biological process
	axon guidance receptor activity		molecular function
	ephrin receptor activity
	integral to plasma membrane		cellular component
	membrane
	nucleotide binding		molecular function
	protein amino acid phosphorylation		biological process
	protein kinase activity		molecular function
	protein serine/threonine kinase activity
	protein-tyrosine kinase activity
	receptor activity
	signal transduction		biological process
	transferase activity		molecular function
	transmembrane receptor protein tyrosine kinase signaling pathway		biological process
3.54414	cell-cell signaling	Toll-interacting protein. [Uniprot/SWISSPROT;Acc:Q9H0E2]
	cytoplasm		cellular component
	immune response		biological process
	inflammatory response
	interleukin-1 receptor complex		cellular component
	interleukin-18 receptor complex
	intracellular signaling cascade		biological process
	leukocyte activation
	phosphorylation

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.