MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Class	Gene Ontology	Accession	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2401 to 2450 of 2667 in total

Regulation  : up

Ratio	description	Class	Gene Ontology
3.32356	Nuclear receptor-interacting protein 3 (Sarcoma antigen NY-SAR-105). [Uniprot/SWISSPROT;Acc:Q9NQ35]	molecular function	sugar binding
3.35536	RNA polymerase-associated protein RTF1 homolog. [Uniprot/SWISSPROT;Acc:Q92541]	biological process	regulation of transcription, DNA-dependent
			transcription
		cellular component	nucleolus
			nucleus
		molecular function	calmodulin binding
3.36725	TAR RNA-binding protein 2 (Trans-activation-responsive RNA-binding protein). [Uniprot/SWISSPROT;Acc:Q15633]	biological process	negative regulation of antiviral response by host
			negative regulation of protein kinase activity
			positive regulation of viral genome replication
			positive regulation of viral protein levels in host cell
			regulation of transcription from RNA polymerase II promoter
			regulation of viral transcription
		cellular component	intracellular
			nucleus
		molecular function	double-stranded RNA binding
			protein binding
			protein heterodimerization activity
3.41415	Voltage-dependent calcium channel gamma-7 subunit (Neuronal voltage- gated calcium channel gamma-7 subunit). [Uniprot/SWISSPROT;Acc:P62955]	biological process	calcium ion transport
			ion transport
		cellular component	integral to membrane
			membrane
			voltage-gated calcium channel complex
		molecular function	calcium ion binding
			voltage-gated calcium channel activity
			voltage-gated ion channel activity
3.41794	LRRC44 protein. [Uniprot/SPTREMBL;Acc:Q6P5P7]		protein binding
3.48558	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2) (Tyrosine-protein kinase TYRO6). [Uniprot/SWISSPROT;Acc:P54753]	biological process	axon guidance
			protein amino acid phosphorylation
			signal transduction
			transmembrane receptor protein tyrosine kinase signaling pathway
		cellular component	integral to plasma membrane
			membrane
		molecular function	ATP binding
			axon guidance receptor activity
			ephrin receptor activity
			nucleotide binding
			protein kinase activity
			protein serine/threonine kinase activity
			protein-tyrosine kinase activity
			receptor activity
			transferase activity
3.54414	Toll-interacting protein. [Uniprot/SWISSPROT;Acc:Q9H0E2]	biological process	cell-cell signaling
			immune response
			inflammatory response
			intracellular signaling cascade
			leukocyte activation
			phosphorylation
		cellular component	cytoplasm
			interleukin-1 receptor complex
			interleukin-18 receptor complex

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.