MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2351 to 2400 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
3.83977	down	AT-hook-containing transcription factor 1 (Embryonic large molecule derived from yolk sac). [Uniprot/SWISSPROT;Acc:Q8WYP5]	cellular component	nucleus
			molecular function	DNA binding
				transcription factor activity
3.89584	up	Kremen protein 1 precursor (Kringle-containing protein marking the eye and the nose) (Kringle domain-containing transmembrane protein 1) (Dickkopf receptor). [Uniprot/SWISSPROT;Acc:Q96MU8]	biological process	cell communication
				Wnt receptor signaling pathway
			cellular component	integral to membrane
				membrane
				membrane fraction
			molecular function	molecular_function
3.99682	down	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein). [Uniprot/SWISSPROT;Acc:Q9P232]	biological process	cell adhesion
				protein amino acid phosphorylation
			cellular component	membrane
			molecular function	ATP binding
				GPI anchor binding
				interleukin-1 receptor activity
				protein binding
				vascular endothelial growth factor receptor activity
4.03725	up	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon). [Uniprot/SWISSPROT;Acc:P23469]	biological process	dephosphorylation
				protein amino acid dephosphorylation
				transmembrane receptor protein tyrosine phosphatase signaling pathway
			cellular component	cytoplasm
				integral to plasma membrane
				membrane
				soluble fraction
			molecular function	hydrolase activity
				phosphoric monoester hydrolase activity
				protein homodimerization activity
				protein tyrosine phosphatase activity
				receptor activity
				transmembrane receptor protein tyrosine phosphatase activity
4.04651		Sad1/unc-84-like protein 2 (Rab5-interacting protein) (Rab5IP). [Uniprot/SWISSPROT;Acc:Q9UH99]	biological process	mitotic spindle organization and biogenesis
				nuclear membrane organization and biogenesis
				nuclear migration
				regulation of transcription, DNA-dependent
			cellular component	condensed nuclear chromosome
				endosome
				integral to membrane
				membrane
				nuclear chromosome, telomeric region
				nuclear envelope
				nucleus
			molecular function	microtubule binding
				protein binding
				protein dimerization activity
				sequence-specific DNA binding
				transcription factor activity
4.05743		Clarin-1 (Usher syndrome type-3 protein). [Uniprot/SWISSPROT;Acc:P58418]	biological process	response to stimulus
				sensory perception of sound
				visual perception
			cellular component	integral to membrane

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.