MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Gene Ontology	Accession	Regulation	Ratio	description	Class	Minimum Ratio	Gene	Maximum Ratio

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Showing element 2351 to 2400 of 2667 in total

Gene Ontology	Regulation	Ratio	description	Class
SRP-dependent cotranslational protein targeting to membrane	down	1.25205	Protein CWC15 homolog. [Uniprot/SWISSPROT;Acc:Q9P013]	biological process
STAT protein nuclear translocation	up	1.61987	Proteinase-activated receptor 1 precursor (PAR-1) (Thrombin receptor) (Coagulation factor II receptor). [Uniprot/SWISSPROT;Acc:P25116]
steroid hormone receptor activity	down	1.98137	Nuclear receptor ROR-alpha (Retinoid-related orphan receptor-alpha) (Nuclear receptor RZR-alpha). [Uniprot/SWISSPROT;Acc:P35398]	molecular function
steroid metabolic process		1.23845	Insulin-induced gene 1 protein (INSIG-1). [Uniprot/SWISSPROT;Acc:O15503]	biological process
		1.30207	Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein). [Uniprot/SWISSPROT;Acc:Q5SW96]
	up	2.43098	Oxysterol-binding protein-related protein 2 (OSBP-related protein 2) (ORP-2). [Uniprot/SWISSPROT;Acc:Q9H1P3]
striated muscle contraction	down	1.24114	Myosin-15 (Myosin heavy chain 15). [Uniprot/SWISSPROT;Acc:Q9Y2K3]
striated muscle development	up	3.70292	Homeobox protein SIX4 (Sine oculis homeobox homolog 4). [Uniprot/SWISSPROT;Acc:Q9UIU6]
striated muscle thick filament	down	1.24114	Myosin-15 (Myosin heavy chain 15). [Uniprot/SWISSPROT;Acc:Q9Y2K3]	cellular component
structural constituent of cell wall		2.51088	Epididymal-specific lipocalin-12 precursor. [Uniprot/SWISSPROT;Acc:Q6JVE5]	molecular function
		7.45006	MAP7 domain containing 1 [RefSeq_peptide;Acc:NP_060537]
	up	1.40749	collagen, type XXVII, alpha 1 [RefSeq_peptide;Acc:NP_116277]
structural constituent of muscle	down	3.39764	Junctophilin-1 (Junctophilin type 1) (JP-1). [Uniprot/SWISSPROT;Acc:Q9HDC5]
structural constituent of ribosome		2.16131	39S ribosomal protein L15, mitochondrial precursor (L15mt) (MRP-L15). [Uniprot/SWISSPROT;Acc:Q9P015]
		2.45383	40S ribosomal protein S2 (S4) (LLRep3 protein). [Uniprot/SWISSPROT;Acc:P15880]
	up	1.42264	RNA-binding protein 4 (RNA-binding motif protein 4) (RNA-binding motif protein 4a) (Lark homolog) (hLark). [Uniprot/SWISSPROT;Acc:Q9BWF3]
		2.70687	Cartilage acidic protein 1 precursor (68 kDa chondrocyte-expressed protein) (CEP-68) (ASPIC). [Uniprot/SWISSPROT;Acc:Q9NQ79]
structural molecule activity	down	1.13541	Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (Nel-related protein 2). [Uniprot/SWISSPROT;Acc:Q99435]
		1.54676	WAS protein homology region 2 domain containing 1 [RefSeq_peptide;Acc:NP_001073904]
		1.72628	Coiled-coil domain-containing protein 108. [Uniprot/SWISSPROT;Acc:Q6ZU64]
		3.05037	Thrombospondin-4 precursor. [Uniprot/SWISSPROT;Acc:P35443]
	up	1.15279	Podocalyxin-like protein 2 precursor (Endoglycan). [Uniprot/SWISSPROT;Acc:Q9NZ53]
		1.21657	Septin-5 (Peanut-like protein 1) (Cell division control-related protein 1) (CDCrel-1). [Uniprot/SWISSPROT;Acc:Q99719]
		1.40749	collagen, type XXVII, alpha 1 [RefSeq_peptide;Acc:NP_116277]
		1.75026	Claudin-11 (Oligodendrocyte-specific protein). [Uniprot/SWISSPROT;Acc:O75508]
		2.37788	Coiled-coil domain-containing protein 83. [Uniprot/SWISSPROT;Acc:Q8IWF9]
substrate-bound cell migration, cell extension	down	3.05037	Thrombospondin-4 precursor. [Uniprot/SWISSPROT;Acc:P35443]	biological process
subtilase activity		1.19134	Proprotein convertase subtilisin/kexin type 6 precursor (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin/kexin-like protease PACE4) (Subtilisin-like proprotein convertase 4) (SPC4). [Uniprot/SWISSPROT;Acc:P29122]	molecular function
sugar binding		2.88128	CD302 antigen precursor (C-type lectin domain family 13 member A) (C- type lectin BIMLEC) (Type I transmembrane C-type lectin receptor DCL- 1). [Uniprot/SWISSPROT;Acc:Q8IX05]
	up	3.32356	Nuclear receptor-interacting protein 3 (Sarcoma antigen NY-SAR-105). [Uniprot/SWISSPROT;Acc:Q9NQ35]
sulfate porter activity		1.31661	Chloride anion exchanger (Protein DRA) (Down-regulated in adenoma) (Solute carrier family 26 member 3). [Uniprot/SWISSPROT;Acc:P40879]
sulfate transport				biological process
sulfur amino acid metabolic process		1.19539	Cysteine desulfurase, mitochondrial precursor (EC 2.8.1.7). [Uniprot/SWISSPROT;Acc:Q9Y697]
symporter activity	down	1.11083	Sodium- and chloride-dependent transporter XTRP3 (Solute carrier family 6 member 20) (Neurotransmitter transporter rB21A homolog). [Uniprot/SWISSPROT;Acc:Q9NP91]	molecular function
		1.40552	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (Amino acid transporter ATB0+) (Solute carrier family 6 member 14). [Uniprot/SWISSPROT;Acc:Q9UN76]
		1.42215	Sodium-dependent serotonin transporter (5HT transporter) (5HTT). [Uniprot/SWISSPROT;Acc:P31645]
synapse		1.24359	Calcium-dependent secretion activator 2 (Calcium-dependent activator protein for secretion 2) (CAPS-2). [Uniprot/SWISSPROT;Acc:Q86UW7]	cellular component
		2.27115	RIM-binding protein 2 (RIM-BP2). [Uniprot/SWISSPROT;Acc:O15034]
	up	1.34001	Protein DmX-like 2 (Rabconnectin-3). [Uniprot/SWISSPROT;Acc:Q8TDJ6]
		2.07532	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP). [Uniprot/SWISSPROT;Acc:Q9Y566]
		2.54508	Neuroligin-2 precursor. [Uniprot/SWISSPROT;Acc:Q8NFZ4]
synaptic transmission		1.2734	Neurexin-2-alpha precursor (Neurexin II-alpha). [Uniprot/SWISSPROT;Acc:Q9P2S2]	biological process
		2.7017	Centromere protein S (CENP-S) (Apoptosis-inducing TAF9-like domain- containing protein 1). [Uniprot/SWISSPROT;Acc:Q8N2Z9]
synaptic vesicle		1.21657	Septin-5 (Peanut-like protein 1) (Cell division control-related protein 1) (CDCrel-1). [Uniprot/SWISSPROT;Acc:Q99719]	cellular component
		1.34001	Protein DmX-like 2 (Rabconnectin-3). [Uniprot/SWISSPROT;Acc:Q8TDJ6]
synaptic vesicle targeting		1.21657	Septin-5 (Peanut-like protein 1) (Cell division control-related protein 1) (CDCrel-1). [Uniprot/SWISSPROT;Acc:Q99719]	biological process
synaptogenesis		1.2734	Neurexin-2-alpha precursor (Neurexin II-alpha). [Uniprot/SWISSPROT;Acc:Q9P2S2]
		2.54508	Neuroligin-2 precursor. [Uniprot/SWISSPROT;Acc:Q8NFZ4]
synaptosome		1.21657	Septin-5 (Peanut-like protein 1) (Cell division control-related protein 1) (CDCrel-1). [Uniprot/SWISSPROT;Acc:Q99719]	cellular component
syntaxin binding				molecular function

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.