MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	Gene Ontology	description	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2318 to 2367 of 2667 in total

Ratio	Regulation	Gene Ontology	description	Class
3.70292	up	regulation of transcription, DNA-dependent	Homeobox protein SIX4 (Sine oculis homeobox homolog 4). [Uniprot/SWISSPROT;Acc:Q9UIU6]	biological process
		response to freezing
		sequence-specific DNA binding		molecular function
		striated muscle development		biological process
		thymus development
		transcription factor activity		molecular function
3.71868	down	nucleus	Protein pelota homolog. [Uniprot/SWISSPROT;Acc:Q9BRX2]	cellular component
		protein binding		molecular function
		translation		biological process
3.74971	up	glutathione peroxidase activity	Glutathione peroxidase 6 precursor (EC 1.11.1.9). [Uniprot/SWISSPROT;Acc:P59796]	molecular function
		oxidoreductase activity
		response to oxidative stress		biological process
		selenium binding		molecular function
3.76904		integral to membrane	Progestin and adipoQ receptor family member 4 (Progestin and adipoQ receptor family member IV). [Uniprot/SWISSPROT;Acc:Q8N4S7]	cellular component
		membrane
		receptor activity		molecular function
3.81736		cell cycle	Transcription factor E2F3 (E2F-3). [Uniprot/SWISSPROT;Acc:O00716]	biological process
		homoiothermy
		ice binding		molecular function
		nucleus		cellular component
		protein binding		molecular function
		regulation of progression through cell cycle		biological process
		regulation of transcription, DNA-dependent
		response to freezing
		transcription
		transcription factor activity		molecular function
		transcription factor complex		cellular component
		transcription initiation from RNA polymerase II promoter		biological process
3.83977	down	cytoplasm	AT-hook-containing transcription factor 1 (Embryonic large molecule derived from yolk sac). [Uniprot/SWISSPROT;Acc:Q8WYP5]	cellular component
		DNA binding		molecular function
		multicellular organismal development		biological process
		nuclear matrix		cellular component
		nucleus
		regulation of transcription		biological process
		transcription
		transcription factor activity		molecular function
3.89584	up	cell communication	Kremen protein 1 precursor (Kringle-containing protein marking the eye and the nose) (Kringle domain-containing transmembrane protein 1) (Dickkopf receptor). [Uniprot/SWISSPROT;Acc:Q96MU8]	biological process
		integral to membrane		cellular component
		membrane
		membrane fraction
		molecular_function		molecular function
		Wnt receptor signaling pathway		biological process
3.99682	down	ATP binding	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein). [Uniprot/SWISSPROT;Acc:Q9P232]	molecular function
		cell adhesion		biological process
		GPI anchor binding		molecular function
		interleukin-1 receptor activity
		membrane		cellular component
		protein amino acid phosphorylation		biological process
		protein binding		molecular function
		vascular endothelial growth factor receptor activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.