MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2318 to 2367 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
3.70292	up	Homeobox protein SIX4 (Sine oculis homeobox homolog 4). [Uniprot/SWISSPROT;Acc:Q9UIU6]	biological process	striated muscle development
				thymus development
			cellular component	nucleus
			molecular function	ice binding
				sequence-specific DNA binding
				transcription factor activity
3.71868	down	Protein pelota homolog. [Uniprot/SWISSPROT;Acc:Q9BRX2]	biological process	translation
			cellular component	nucleus
			molecular function	protein binding
3.74971	up	Glutathione peroxidase 6 precursor (EC 1.11.1.9). [Uniprot/SWISSPROT;Acc:P59796]	biological process	response to oxidative stress
			molecular function	glutathione peroxidase activity
				oxidoreductase activity
				selenium binding
3.76904		Progestin and adipoQ receptor family member 4 (Progestin and adipoQ receptor family member IV). [Uniprot/SWISSPROT;Acc:Q8N4S7]	cellular component	integral to membrane
				membrane
			molecular function	receptor activity
3.81736		Transcription factor E2F3 (E2F-3). [Uniprot/SWISSPROT;Acc:O00716]	biological process	cell cycle
				homoiothermy
				regulation of progression through cell cycle
				regulation of transcription, DNA-dependent
				response to freezing
				transcription
				transcription initiation from RNA polymerase II promoter
			cellular component	nucleus
				transcription factor complex
			molecular function	ice binding
				protein binding
				transcription factor activity
3.83977	down	AT-hook-containing transcription factor 1 (Embryonic large molecule derived from yolk sac). [Uniprot/SWISSPROT;Acc:Q8WYP5]	biological process	multicellular organismal development
				regulation of transcription
				transcription
			cellular component	cytoplasm
				nuclear matrix
				nucleus
			molecular function	DNA binding
				transcription factor activity
3.89584	up	Kremen protein 1 precursor (Kringle-containing protein marking the eye and the nose) (Kringle domain-containing transmembrane protein 1) (Dickkopf receptor). [Uniprot/SWISSPROT;Acc:Q96MU8]	biological process	cell communication
				Wnt receptor signaling pathway
			cellular component	integral to membrane
				membrane
				membrane fraction
			molecular function	molecular_function
3.99682	down	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein). [Uniprot/SWISSPROT;Acc:Q9P232]	biological process	cell adhesion
				protein amino acid phosphorylation
			cellular component	membrane
			molecular function	ATP binding
				GPI anchor binding
				interleukin-1 receptor activity
				protein binding
				vascular endothelial growth factor receptor activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.