MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Class	Gene Ontology	Accession	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2318 to 2367 of 2667 in total

Regulation  : up

Ratio	description	Class	Gene Ontology
2.86538	Olfactory receptor 1J2 (Olfactory receptor OR9-19) (OST044) (HSA5) (HTPCRX15). [Uniprot/SWISSPROT;Acc:Q8NGS2]	cellular component	integral to membrane
		molecular function	cannabinoid receptor activity
			olfactory receptor activity
			receptor activity
			rhodopsin-like receptor activity
2.86965	RNA-binding protein 28 (RNA-binding motif protein 28). [Uniprot/SWISSPROT;Acc:Q9NW13]	biological process	DNA topological change
		cellular component	chromosome
			nucleus
		molecular function	ATP binding
			DNA binding
			DNA topoisomerase (ATP-hydrolyzing) activity
			nucleic acid binding
			nucleotide binding
			RNA binding
2.87038	Calpain-3 (EC 3.4.22.54) (Calpain L3) (Calpain p94) (Calcium-activated neutral proteinase 3) (CANP 3) (Muscle-specific calcium-activated neutral protease 3) (nCL-1). [Uniprot/SWISSPROT;Acc:P20807]	biological process	muscle development
			proteolysis
			response to calcium ion
			response to drug
			sarcomere organization
		cellular component	cytoplasm
			intracellular
			nucleus
		molecular function	calcium ion binding
			calpain activity
			cysteine-type endopeptidase activity
			peptidase activity
			protein binding
			signal transducer activity
2.91954	Cisplatin resistance-associated overexpressed protein (cAMP regulatory element-associated protein 1) (CRE-associated protein 1) (CREAP-1) (Luc7A) (Okadaic acid-inducible phosphoprotein OA48-18). [Uniprot/SWISSPROT;Acc:O95232]	biological process	apoptosis
			response to stress
			RNA splicing
		cellular component	nucleus
		molecular function	DNA binding
			protein binding
2.95579	Protein phosphatase Slingshot homolog 3 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-3L) (hSSH-3L). [Uniprot/SWISSPROT;Acc:Q8TE77]	biological process	dephosphorylation
			protein amino acid dephosphorylation
		cellular component	cytoplasm
			cytoskeleton
			nucleus
		molecular function	hydrolase activity
			phosphoric monoester hydrolase activity
			protein tyrosine phosphatase activity
			protein tyrosine/serine/threonine phosphatase activity
2.96739	Protein FRA10AC1. [Uniprot/SWISSPROT;Acc:Q70Z53]	cellular component	nucleus
		molecular function	protein binding
3.03423	Suppressor of G2 allele of SKP1 homolog (Sgt1) (Putative 40-6-3 protein). [Uniprot/SWISSPROT;Acc:Q9Y2Z0]	biological process	mitosis
			regulation of progression through cell cycle
			ubiquitin cycle
		cellular component	kinetochore
			ubiquitin ligase complex

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.