MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Gene Ontology	Ratio	Accession	Minimum Ratio	Regulation	description	Gene	Class	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2301 to 2350 of 2667 in total

Gene Ontology	Ratio	Regulation	description	Class
signal transduction	1.89308	up	Ras-related protein Rab-36. [Uniprot/SWISSPROT;Acc:O95755]	biological process
	1.93863		Olfactory receptor 2B2 (Olfactory receptor 6-1) (OR6-1) (Hs6M1-10). [Uniprot/SWISSPROT;Acc:Q9GZK3]
	1.95876		Ras-related protein Rab-17. [Uniprot/SWISSPROT;Acc:Q9H0T7]
	1.98137	down	Nuclear receptor ROR-alpha (Retinoid-related orphan receptor-alpha) (Nuclear receptor RZR-alpha). [Uniprot/SWISSPROT;Acc:P35398]
	2.44552		Guanine nucleotide-binding protein alpha-14 subunit (G-protein alpha subunit 14). [Uniprot/SWISSPROT;Acc:O95837]
	2.93895		TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF). [Uniprot/SWISSPROT;Acc:Q92844]
	3.27919		Calsenilin (Kv channel-interacting protein 3) (KChIP3) (A-type potassium channel modulatory protein 3) (DRE-antagonist modulator) (DREAM). [Uniprot/SWISSPROT;Acc:Q9Y2W7]
	3.48558	up	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2) (Tyrosine-protein kinase TYRO6). [Uniprot/SWISSPROT;Acc:P54753]
	3.52215	down	Olfactory receptor 4L1 (Olfactory receptor OR14-28). [Uniprot/SWISSPROT;Acc:Q8NH43]
	3.54799		Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta 2 (Transducin beta chain 2) (G protein beta 2 subunit). [Uniprot/SWISSPROT;Acc:P62879]
	3.64872	up	GTP-binding protein Rhes precursor (Ras homolog enriched in striatum) (Tumor endothelial marker 2). [Uniprot/SWISSPROT;Acc:Q96D21]
	4.55371		Parathyroid hormone/parathyroid hormone-related peptide receptor precursor (PTH/PTHr receptor) (PTH/PTHrP type I receptor). [Uniprot/SWISSPROT;Acc:Q03431]
	5.53059		rab and DnaJ domain containing [RefSeq_peptide;Acc:NP_057628]
single fertilization	5.83544	down	Nucleoplasmin-2. [Uniprot/SWISSPROT;Acc:Q86SE8]
skeletal development	1.30142		Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen). [Uniprot/SWISSPROT;Acc:P22607]
	4.55371	up	Parathyroid hormone/parathyroid hormone-related peptide receptor precursor (PTH/PTHr receptor) (PTH/PTHrP type I receptor). [Uniprot/SWISSPROT;Acc:Q03431]
small conjugating protein ligase activity	1.49444		Ubiquitin-conjugating enzyme E2 R2 (EC 6.3.2.19) (Ubiquitin-protein ligase R2) (Ubiquitin carrier protein R2) (E2-CDC34B). [Uniprot/SWISSPROT;Acc:Q712K3]	molecular function
	1.59763	down	Ubiquitin-conjugating enzyme E2 Q2 (EC 6.3.2.19) (Ubiquitin-protein ligase Q2) (Ubiquitin carrier protein Q2). [Uniprot/SWISSPROT;Acc:Q8WVN8]
small GTPase mediated signal transduction	1.21657	up	Septin-5 (Peanut-like protein 1) (Cell division control-related protein 1) (CDCrel-1). [Uniprot/SWISSPROT;Acc:Q99719]	biological process
	1.40602		GTP-binding protein SAR1a (COPII-associated small GTPase). [Uniprot/SWISSPROT;Acc:Q9NR31]
	1.49923	down	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP). [Uniprot/SWISSPROT;Acc:Q13905]
	1.7961	up	RAS-like, family 11, member A [RefSeq_peptide;Acc:NP_996563]
	1.89308		Ras-related protein Rab-36. [Uniprot/SWISSPROT;Acc:O95755]
	1.95876		Ras-related protein Rab-17. [Uniprot/SWISSPROT;Acc:Q9H0T7]
	3.64872		GTP-binding protein Rhes precursor (Ras homolog enriched in striatum) (Tumor endothelial marker 2). [Uniprot/SWISSPROT;Acc:Q96D21]
	5.31521		Rho-related BTB domain-containing protein 1. [Uniprot/SWISSPROT;Acc:O94844]
	5.53059		rab and DnaJ domain containing [RefSeq_peptide;Acc:NP_057628]
small GTPase regulator activity	1.80858	down	Rhophilin-1 (GTP-Rho-binding protein 1). [Uniprot/SWISSPROT;Acc:Q8TCX5]	molecular function
small ribosomal subunit	2.45383		40S ribosomal protein S2 (S4) (LLRep3 protein). [Uniprot/SWISSPROT;Acc:P15880]	cellular component
sodium ion binding	1.20619		Sodium/potassium-transporting ATPase subunit alpha-4 (EC 3.6.3.9) (Sodium pump subunit alpha-4) (Na(+)/K(+) ATPase alpha-4 subunit). [Uniprot/SWISSPROT;Acc:Q13733]	molecular function
sodium ion transport				biological process
sodium:dicarboxylate symporter activity	1.40552		Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (Amino acid transporter ATB0+) (Solute carrier family 6 member 14). [Uniprot/SWISSPROT;Acc:Q9UN76]	molecular function
	4.67988	up	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (HPCN3) (HGK5) (HuKIII) (HLK3). [Uniprot/SWISSPROT;Acc:P22001]
sodium:potassium-exchanging ATPase activity	1.20619	down	Sodium/potassium-transporting ATPase subunit alpha-4 (EC 3.6.3.9) (Sodium pump subunit alpha-4) (Na(+)/K(+) ATPase alpha-4 subunit). [Uniprot/SWISSPROT;Acc:Q13733]
sodium:potassium-exchanging ATPase complex				cellular component
soluble fraction	1.44004		Cytokine-like protein 1 precursor (Protein C17). [Uniprot/SWISSPROT;Acc:Q9NRR1]
	1.83496	up	Protein FAN (Factor associated with N-SMase activation) (Factor associated with neutral sphingomyelinase activation). [Uniprot/SWISSPROT;Acc:Q92636]
	1.98149		CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (TNF-related activation protein) (TRAP) (T cell antigen Gp39) (CD154 antigen) [Contains: CD40 ligand, membrane form; CD40 ligand, soluble form]. [Uniprot/SWISSPROT;Acc:P29965]
	2.7017		Centromere protein S (CENP-S) (Apoptosis-inducing TAF9-like domain- containing protein 1). [Uniprot/SWISSPROT;Acc:Q8N2Z9]
	4.03725		Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon). [Uniprot/SWISSPROT;Acc:P23469]
specific RNA polymerase II transcription factor activity	1.89168	down	Zinc finger protein 202 (Zinc finger protein with KRAB and SCAN domains 10). [Uniprot/SWISSPROT;Acc:O95125]	molecular function
specific transcriptional repressor activity	3.27919		Calsenilin (Kv channel-interacting protein 3) (KChIP3) (A-type potassium channel modulatory protein 3) (DRE-antagonist modulator) (DREAM). [Uniprot/SWISSPROT;Acc:Q9Y2W7]
sperm motility	1.20619		Sodium/potassium-transporting ATPase subunit alpha-4 (EC 3.6.3.9) (Sodium pump subunit alpha-4) (Na(+)/K(+) ATPase alpha-4 subunit). [Uniprot/SWISSPROT;Acc:Q13733]	biological process
spermatogenesis	1.36349		Cyclin-I. [Uniprot/SWISSPROT;Acc:Q14094]
	1.75026	up	Claudin-11 (Oligodendrocyte-specific protein). [Uniprot/SWISSPROT;Acc:O75508]
spindle	2.75048		SAC3 domain containing 1 [RefSeq_peptide;Acc:NP_037431]	cellular component
spindle assembly				biological process
spindle microtubule	1.2984	down	nucleolar and spindle associated protein 1 isoform 2 [RefSeq_peptide;Acc:NP_060924]	cellular component
spliceosome	1.25205		Protein CWC15 homolog. [Uniprot/SWISSPROT;Acc:Q9P013]
	3.43019		Pre-mRNA-splicing factor SYF2 (CCNDBP1-interactor) (p29). [Uniprot/SWISSPROT;Acc:O95926]

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.