MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2268 to 2317 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
3.54414	up	Toll-interacting protein. [Uniprot/SWISSPROT;Acc:Q9H0E2]	biological process	inflammatory response
				intracellular signaling cascade
				leukocyte activation
				phosphorylation
			cellular component	cytoplasm
				interleukin-1 receptor complex
				interleukin-18 receptor complex
			molecular function	protein binding
				signal transducer activity
				Toll binding
3.54799	down	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta 2 (Transducin beta chain 2) (G protein beta 2 subunit). [Uniprot/SWISSPROT;Acc:P62879]	biological process	G-protein coupled receptor protein signaling pathway
				signal transduction
			molecular function	calcium channel regulator activity
				GTPase activity
				protein binding
				signal transducer activity
3.54928		Glycerophosphodiester phosphodiesterase domain-containing protein 5 (EC 3.1.-.-) (Glycerophosphodiester phosphodiesterase 2). [Uniprot/SWISSPROT;Acc:Q8WTR4]	biological process	glycerol metabolic process
			cellular component	cytoplasm
				integral to membrane
				membrane
			molecular function	glycerophosphodiester phosphodiesterase activity
				hydrolase activity
3.62109		Hematological and neurological expressed 1 protein (Androgen-regulated protein 2). [Uniprot/SWISSPROT;Acc:Q9UK76]	cellular component	nucleus
3.64872	up	GTP-binding protein Rhes precursor (Ras homolog enriched in striatum) (Tumor endothelial marker 2). [Uniprot/SWISSPROT;Acc:Q96D21]	biological process	intracellular protein transport
				locomotory behavior
				nucleocytoplasmic transport
				protein transport
				signal transduction
				small GTPase mediated signal transduction
			cellular component	cellular_component
				intracellular
				membrane
			molecular function	GTP binding
				GTPase activity
				nucleotide binding
				protein binding
3.66058	down	olfactomedin-like 2A [RefSeq_peptide;Acc:NP_872293]	cellular component	extracellular matrix
				membrane
			molecular function	extracellular matrix binding
				latrotoxin receptor activity
				protein homodimerization activity
3.70292	up	Homeobox protein SIX4 (Sine oculis homeobox homolog 4). [Uniprot/SWISSPROT;Acc:Q9UIU6]	biological process	anatomical structure development
				embryonic skeletal morphogenesis
				homoiothermy
				inner ear morphogenesis
				multicellular organismal development
				myoblast migration
				positive regulation of transcription
				regulation of transcription, DNA-dependent
				response to freezing

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.