MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Gene Ontology	Class	Gene	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 218 to 267 of 2667 in total

Regulation  : down

Ratio	description	Gene Ontology	Class
1.24361	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IA) (Alpha-1,2-mannosidase IA) (Mannosidase alpha class 1A member 1) (Man(9)-alpha-mannosidase) (Man9-mannosidase). [Uniprot/SWISSPROT;Acc:P33908]	protein amino acid glycosylation	biological process
1.24964	Atlastin-2 (ADP-ribosylation factor-like protein 6-interacting protein 2). [Uniprot/SWISSPROT;Acc:Q8NHH9]	GTP binding	molecular function
		GTPase activity
		immune response	biological process
		integral to membrane	cellular component
		membrane
		nucleotide binding	molecular function
		protein binding
1.25113	Zinc finger protein OZF (Only zinc finger protein) (Zinc finger protein 146). [Uniprot/SWISSPROT;Acc:Q15072]	DNA binding
		heparin binding
		intracellular	cellular component
		metal ion binding	molecular function
		nucleic acid binding
		nucleus	cellular component
		regulation of transcription, DNA-dependent	biological process
		zinc ion binding	molecular function
1.25205	Protein CWC15 homolog. [Uniprot/SWISSPROT;Acc:Q9P013]	7S RNA binding
		GTP binding
		membrane	cellular component
		nuclear mRNA splicing, via spliceosome	biological process
		nucleus	cellular component
		RNA binding	molecular function
		RNA splicing	biological process
		spliceosome	cellular component
		SRP-dependent cotranslational protein targeting to membrane	biological process
1.27461	Homeobox protein Hox-D3 (Hox-4A). [Uniprot/SWISSPROT;Acc:P31249]	anatomical structure morphogenesis
		DNA binding	molecular function
		G-protein coupled receptor protein signaling pathway	biological process
		galanin receptor activity	molecular function
		integral to membrane	cellular component
		multicellular organismal development	biological process
		nucleus	cellular component
		regulation of transcription, DNA-dependent	biological process
		sequence-specific DNA binding	molecular function
		thyroid gland development	biological process
		transcription factor activity	molecular function
1.27696	Speedy protein A (Speedy-1) (Spy1) (Rapid inducer of G2/M progression in oocytes A) (RINGO A) (hSpy/Ringo A). [Uniprot/SWISSPROT;Acc:Q5MJ70]	cell cycle	biological process
		G1/S transition of mitotic cell cycle
		multicellular organismal development
		nucleus	cellular component
		positive regulation of cell proliferation	biological process
		positive regulation of cyclin-dependent protein kinase activity
		protein amino acid dephosphorylation
		protein binding	molecular function
		protein kinase binding
		protein phosphatase type 1 activity
		regulation of progression through cell cycle	biological process
		response to DNA damage stimulus
1.27802	Melanoma-associated antigen B2 (MAGE-B2 antigen) (DSS-AHC critical interval MAGE superfamily 6) (DAM6) (MAGE XP-2). [Uniprot/SWISSPROT;Acc:O15479]	homoiothermy
		ice binding	molecular function

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.