MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	Gene Ontology	description	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2168 to 2217 of 2667 in total

Ratio	Regulation	Gene Ontology	description	Class
3.29064	down	metal ion binding	Transcription factor GATA-6 (GATA-binding factor 6). [Uniprot/SWISSPROT;Acc:Q92908]	molecular function
		muscle development		biological process
		nucleus		cellular component
		positive regulation of transcription		biological process
		positive regulation of transcription from RNA polymerase II promoter
		protein binding		molecular function
		regulation of transcription, DNA-dependent		biological process
		RNA polymerase II transcription factor activity, enhancer binding		molecular function
		sequence-specific DNA binding
		transcription		biological process
		transcription factor activity		molecular function
		transcriptional activator activity
		zinc ion binding
3.31364	up	2-acylglycerol O-acyltransferase activity	Diacylglycerol O-acyltransferase 2 (EC 2.3.1.20) (Diglyceride acyltransferase 2). [Uniprot/SWISSPROT;Acc:Q96PD7]
		acyltransferase activity
		diacylglycerol O-acyltransferase activity
		endoplasmic reticulum		cellular component
		glycerol metabolic process		biological process
		integral to membrane		cellular component
		lipid biosynthetic process		biological process
		lipid metabolic process
		membrane		cellular component
		membrane fraction
		transferase activity		molecular function
		triacylglycerol biosynthetic process		biological process
3.32356		aspartic-type endopeptidase activity	Nuclear receptor-interacting protein 3 (Sarcoma antigen NY-SAR-105). [Uniprot/SWISSPROT;Acc:Q9NQ35]	molecular function
		proteolysis		biological process
		sugar binding		molecular function
3.35536		calmodulin binding	RNA polymerase-associated protein RTF1 homolog. [Uniprot/SWISSPROT;Acc:Q92541]
		nucleolus		cellular component
		nucleus
		regulation of transcription, DNA-dependent		biological process
		transcription
3.36725		double-stranded RNA binding	TAR RNA-binding protein 2 (Trans-activation-responsive RNA-binding protein). [Uniprot/SWISSPROT;Acc:Q15633]	molecular function
		intracellular		cellular component
		negative regulation of antiviral response by host		biological process
		negative regulation of protein kinase activity
		nucleus		cellular component
		positive regulation of viral genome replication		biological process
		positive regulation of viral protein levels in host cell
		protein binding		molecular function
		protein heterodimerization activity
		regulation of transcription from RNA polymerase II promoter		biological process
		regulation of viral transcription
3.39764	down	biological_process	Junctophilin-1 (Junctophilin type 1) (JP-1). [Uniprot/SWISSPROT;Acc:Q9HDC5]
		integral to membrane		cellular component
		junctional membrane complex
		membrane
		microsome
		molecular_function		molecular function

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.