MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2155 to 2204 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
3.27919	down	Calsenilin (Kv channel-interacting protein 3) (KChIP3) (A-type potassium channel modulatory protein 3) (DRE-antagonist modulator) (DREAM). [Uniprot/SWISSPROT;Acc:Q9Y2W7]	molecular function	calcium ion binding
				calcium-dependent protein binding
				DNA binding
				ion channel activity
				potassium channel activity
				potassium ion binding
				protein C-terminus binding
				specific transcriptional repressor activity
				transcription corepressor activity
				voltage-gated ion channel activity
3.29064		Transcription factor GATA-6 (GATA-binding factor 6). [Uniprot/SWISSPROT;Acc:Q92908]	biological process	liver development
				muscle development
				positive regulation of transcription
				positive regulation of transcription from RNA polymerase II promoter
				regulation of transcription, DNA-dependent
				transcription
			cellular component	nucleus
			molecular function	chromatin binding
				DNA binding
				metal ion binding
				protein binding
				RNA polymerase II transcription factor activity, enhancer binding
				sequence-specific DNA binding
				transcription factor activity
				transcriptional activator activity
				zinc ion binding
3.31364	up	Diacylglycerol O-acyltransferase 2 (EC 2.3.1.20) (Diglyceride acyltransferase 2). [Uniprot/SWISSPROT;Acc:Q96PD7]	biological process	glycerol metabolic process
				lipid biosynthetic process
				lipid metabolic process
				triacylglycerol biosynthetic process
			cellular component	endoplasmic reticulum
				integral to membrane
				membrane
				membrane fraction
			molecular function	2-acylglycerol O-acyltransferase activity
				acyltransferase activity
				diacylglycerol O-acyltransferase activity
				transferase activity
3.32356		Nuclear receptor-interacting protein 3 (Sarcoma antigen NY-SAR-105). [Uniprot/SWISSPROT;Acc:Q9NQ35]	biological process	proteolysis
			molecular function	aspartic-type endopeptidase activity
				sugar binding
3.35536		RNA polymerase-associated protein RTF1 homolog. [Uniprot/SWISSPROT;Acc:Q92541]	biological process	regulation of transcription, DNA-dependent
				transcription
			cellular component	nucleolus
				nucleus
			molecular function	calmodulin binding
3.36725		TAR RNA-binding protein 2 (Trans-activation-responsive RNA-binding protein). [Uniprot/SWISSPROT;Acc:Q15633]	biological process	negative regulation of antiviral response by host
				negative regulation of protein kinase activity
				positive regulation of viral genome replication
				positive regulation of viral protein levels in host cell

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.