MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	Gene Ontology	description	Accession	Class	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2101 to 2150 of 2667 in total

Regulation  : up

Ratio	Gene Ontology	description	Class
1.95876	small GTPase mediated signal transduction	Ras-related protein Rab-17. [Uniprot/SWISSPROT;Acc:Q9H0T7]	biological process
1.96673	endoplasmic reticulum	Signal peptidase complex catalytic subunit SEC11C (EC 3.4.-.-) (SEC11 homolog C) (SEC11-like protein 3) (Microsomal signal peptidase 21 kDa subunit) (SPase 21 kDa subunit) (SPC21). [Uniprot/SWISSPROT;Acc:Q9BY50]	cellular component
	integral to membrane
	membrane
	microsome
	peptidase activity		molecular function
	proteolysis		biological process
	serine-type peptidase activity		molecular function
	signal peptide processing		biological process
1.98149	anti-apoptosis	CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (TNF-related activation protein) (TRAP) (T cell antigen Gp39) (CD154 antigen) [Contains: CD40 ligand, membrane form; CD40 ligand, soluble form]. [Uniprot/SWISSPROT;Acc:P29965]
	B cell differentiation
	B cell proliferation
	CD40 receptor binding		molecular function
	cytokine activity
	extracellular space		cellular component
	immune response		biological process
	inflammatory response
	integral to membrane		cellular component
	integral to plasma membrane
	isotype switching		biological process
	leukocyte adhesion
	membrane		cellular component
	platelet activation		biological process
	regulation of immunoglobulin secretion
	soluble fraction		cellular component
	tumor necrosis factor receptor binding		molecular function
2.07532	cell junction	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP). [Uniprot/SWISSPROT;Acc:Q9Y566]	cellular component
	cytoplasm
	cytoskeletal anchoring		biological process
	dendrite		cellular component
	intracellular
	membrane fraction
	postsynaptic membrane
	protein binding		molecular function
	synapse		cellular component
2.10428	cellular process	Transcription factor AP-1 (Activator protein 1) (AP1) (Proto-oncogene c-jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39). [Uniprot/SWISSPROT;Acc:P05412]	biological process
	DNA binding		molecular function
	leading edge cell differentiation		biological process
	negative regulation of protein amino acid autophosphorylation
	nuclear chromosome		cellular component
	nucleus
	positive regulation of transcription from RNA polymerase II promoter		biological process
	protein dimerization activity		molecular function
	regulation of progression through cell cycle		biological process
	regulation of transcription
	regulation of transcription, DNA-dependent
	RNA polymerase II transcription factor activity		molecular function
	sequence-specific DNA binding
	transcription factor activity
	transcription factor complex		cellular component

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.