Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Gene Ontology Accession Ratio Regulation Minimum Ratio description Class Gene Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2069 to 2118 of 2667 in total

Class

: biological process

Gene Ontology	Ratio	Regulation	description
regulation of growth	1.13541	down	Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (Nel-related protein 2). [Uniprot/SWISSPROT;Acc:Q99435]
regulation of GTPase activity	1.23783	down	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein). [Uniprot/SWISSPROT;Acc:Q8WZ64]
regulation of immunoglobulin secretion	1.98149	up	CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (TNF-related activation protein) (TRAP) (T cell antigen Gp39) (CD154 antigen) [Contains: CD40 ligand, membrane form; CD40 ligand, soluble form]. [Uniprot/SWISSPROT;Acc:P29965]
regulation of inflammatory response	1.18096	down	Prostaglandin G/H synthase 2 precursor (EC 1.14.99.1) (Cyclooxygenase- 2) (COX-2) (Prostaglandin-endoperoxide synthase 2) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (PHS II). [Uniprot/SWISSPROT;Acc:P35354]
regulation of microtubule polymerization or depolymerization	1.29151	up	CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (hOrbit2). [Uniprot/SWISSPROT;Acc:O75122]
regulation of neuron apoptosis	3.27919	down	Calsenilin (Kv channel-interacting protein 3) (KChIP3) (A-type potassium channel modulatory protein 3) (DRE-antagonist modulator) (DREAM). [Uniprot/SWISSPROT;Acc:Q9Y2W7]
regulation of neuron differentiation	1.14311	down	14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1). [Uniprot/SWISSPROT;Acc:P61981]
regulation of progression through cell cycle	1.16823	up	S-phase kinase-associated protein 2 (F-box protein Skp2) (Cyclin A/CDK2-associated protein p45) (p45skp2) (F-box/LRR-repeat protein 1). [Uniprot/SWISSPROT;Acc:Q13309]
	1.18096	down	Prostaglandin G/H synthase 2 precursor (EC 1.14.99.1) (Cyclooxygenase- 2) (COX-2) (Prostaglandin-endoperoxide synthase 2) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (PHS II). [Uniprot/SWISSPROT;Acc:P35354]
	1.21705	up	T-complex protein 1 subunit beta (TCP-1-beta) (CCT-beta). [Uniprot/SWISSPROT;Acc:P78371]
	1.27696	down	Speedy protein A (Speedy-1) (Spy1) (Rapid inducer of G2/M progression in oocytes A) (RINGO A) (hSpy/Ringo A). [Uniprot/SWISSPROT;Acc:Q5MJ70]
	1.29952	down	Melanoma-associated antigen C2 (MAGE-C2 antigen) (MAGE-E1 antigen) (Hepatocellular carcinoma-associated antigen 587) (Cancer-testis antigen 10) (CT10). [Uniprot/SWISSPROT;Acc:Q9UBF1]
	1.35125	up	Geminin. [Uniprot/SWISSPROT;Acc:O75496]
	1.36349	down	Cyclin-I. [Uniprot/SWISSPROT;Acc:Q14094]
	1.45635	up	Cyclin-A2 (Cyclin-A). [Uniprot/SWISSPROT;Acc:P20248]
	1.48363	down	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu). [Uniprot/SWISSPROT;Acc:P30291]
	1.61987	up	Proteinase-activated receptor 1 precursor (PAR-1) (Thrombin receptor) (Coagulation factor II receptor). [Uniprot/SWISSPROT;Acc:P25116]
	1.73211	down	Antigen KI-67. [Uniprot/SWISSPROT;Acc:P46013]
	1.82311	down	Fibroblast growth factor 5 precursor (FGF-5) (HBGF-5) (Smag-82). [Uniprot/SWISSPROT;Acc:P12034]
	2.10428	up	Transcription factor AP-1 (Activator protein 1) (AP1) (Proto-oncogene c-jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39). [Uniprot/SWISSPROT;Acc:P05412]
	3.03423		Suppressor of G2 allele of SKP1 homolog (Sgt1) (Putative 40-6-3 protein). [Uniprot/SWISSPROT;Acc:Q9Y2Z0]
	3.81736		Transcription factor E2F3 (E2F-3). [Uniprot/SWISSPROT;Acc:O00716]
regulation of protein binding	1.30207	down	Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein). [Uniprot/SWISSPROT;Acc:Q5SW96]
regulation of sensory perception of pain	1.61987	up	Proteinase-activated receptor 1 precursor (PAR-1) (Thrombin receptor) (Coagulation factor II receptor). [Uniprot/SWISSPROT;Acc:P25116]
regulation of signal transduction	1.14311	down	14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1). [Uniprot/SWISSPROT;Acc:P61981]
regulation of small GTPase mediated signal transduction	1.49923		Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP). [Uniprot/SWISSPROT;Acc:Q13905]
regulation of synaptic plasticity	1.14311		14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1). [Uniprot/SWISSPROT;Acc:P61981]
regulation of transcription	1.16921	up	Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1). [Uniprot/SWISSPROT;Acc:Q96HZ4]
	1.30082	down	CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2). [Uniprot/SWISSPROT;Acc:Q9NZN8]
	1.45624	up	Transcription factor NF-E2 45 kDa subunit (Nuclear factor, erythroid- derived 2 45 kDa subunit) (p45 NF-E2) (Leucine zipper protein NF-E2). [Uniprot/SWISSPROT;Acc:Q16621]
	1.49558	down	Bone morphogenetic protein 2 precursor (BMP-2) (BMP-2A). [Uniprot/SWISSPROT;Acc:P12643]
	1.69345	up	GC-rich sequence DNA-binding factor (GCF) (Transcription factor 9) (TCF-9). [Uniprot/SWISSPROT;Acc:P16383]
	2.10428	up	Transcription factor AP-1 (Activator protein 1) (AP1) (Proto-oncogene c-jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39). [Uniprot/SWISSPROT;Acc:P05412]
	3.83977	down	AT-hook-containing transcription factor 1 (Embryonic large molecule derived from yolk sac). [Uniprot/SWISSPROT;Acc:Q8WYP5]
	4.4149		X box-binding protein 1 (XBP-1) (Tax-responsive element-binding protein 5). [Uniprot/SWISSPROT;Acc:P17861]
	5.32612		Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (T cell transcription factor NFAT4) (NF-AT4) (NFATx). [Uniprot/SWISSPROT;Acc:Q12968]
regulation of transcription from RNA polymerase II promoter	1.16921	up	Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1). [Uniprot/SWISSPROT;Acc:Q96HZ4]
	1.45624		Transcription factor NF-E2 45 kDa subunit (Nuclear factor, erythroid- derived 2 45 kDa subunit) (p45 NF-E2) (Leucine zipper protein NF-E2). [Uniprot/SWISSPROT;Acc:Q16621]
	1.78439		Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta). [Uniprot/SWISSPROT;Acc:Q14839]
	3.27919	down	Calsenilin (Kv channel-interacting protein 3) (KChIP3) (A-type potassium channel modulatory protein 3) (DRE-antagonist modulator) (DREAM). [Uniprot/SWISSPROT;Acc:Q9Y2W7]
	3.36725	up	TAR RNA-binding protein 2 (Trans-activation-responsive RNA-binding protein). [Uniprot/SWISSPROT;Acc:Q15633]
	5.32612	down	Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (T cell transcription factor NFAT4) (NF-AT4) (NFATx). [Uniprot/SWISSPROT;Acc:Q12968]
regulation of transcription, DNA-dependent	1.10889	up	Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR). [Uniprot/SWISSPROT;Acc:Q96F24]
	1.1243	down	Zinc finger protein basonuclin-2. [Uniprot/SWISSPROT;Acc:Q6ZN30]
	1.13007	up	Zinc finger protein 219. [Uniprot/SWISSPROT;Acc:Q9P2Y4]
	1.16921		Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1). [Uniprot/SWISSPROT;Acc:Q96HZ4]
	1.22576		Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1). [Uniprot/SWISSPROT;Acc:Q9UIS9]
	1.25113	down	Zinc finger protein OZF (Only zinc finger protein) (Zinc finger protein 146). [Uniprot/SWISSPROT;Acc:Q15072]
	1.25808	up	Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Uniprot/SWISSPROT;Acc:Q9P2D1]
	1.27461	down	Homeobox protein Hox-D3 (Hox-4A). [Uniprot/SWISSPROT;Acc:P31249]

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.

- http://analysis.yellowcouch.org/