MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2069 to 2118 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
2.91954	up	Cisplatin resistance-associated overexpressed protein (cAMP regulatory element-associated protein 1) (CRE-associated protein 1) (CREAP-1) (Luc7A) (Okadaic acid-inducible phosphoprotein OA48-18). [Uniprot/SWISSPROT;Acc:O95232]	molecular function	protein binding
2.93895	down	TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF). [Uniprot/SWISSPROT;Acc:Q92844]	biological process	I-kappaB kinase/NF-kappaB cascade
				signal transduction
			cellular component	cytoplasm
			molecular function	metal ion binding
				protein binding
				zinc ion binding
2.95579	up	Protein phosphatase Slingshot homolog 3 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-3L) (hSSH-3L). [Uniprot/SWISSPROT;Acc:Q8TE77]	biological process	dephosphorylation
				protein amino acid dephosphorylation
			cellular component	cytoplasm
				cytoskeleton
				nucleus
			molecular function	hydrolase activity
				phosphoric monoester hydrolase activity
				protein tyrosine phosphatase activity
				protein tyrosine/serine/threonine phosphatase activity
2.96739		Protein FRA10AC1. [Uniprot/SWISSPROT;Acc:Q70Z53]	cellular component	nucleus
			molecular function	protein binding
3.00923	down	Arylamine N-acetyltransferase 1 (EC 2.3.1.5) (Arylamide acetylase 1) (Monomorphic arylamine N-acetyltransferase) (MNAT) (N- acetyltransferase type 1) (NAT-1). [Uniprot/SWISSPROT;Acc:P18440]	biological process	metabolic process
			cellular component	cytoplasm
			molecular function	acetyltransferase activity
				arylamine N-acetyltransferase activity
				transferase activity
3.03423	up	Suppressor of G2 allele of SKP1 homolog (Sgt1) (Putative 40-6-3 protein). [Uniprot/SWISSPROT;Acc:Q9Y2Z0]	biological process	mitosis
				regulation of progression through cell cycle
				ubiquitin cycle
			cellular component	kinetochore
				ubiquitin ligase complex
			molecular function	binding
3.05037	down	Thrombospondin-4 precursor. [Uniprot/SWISSPROT;Acc:P35443]	biological process	cell adhesion
				substrate-bound cell migration, cell extension
			cellular component	extracellular region
				proteinaceous extracellular matrix
			molecular function	calcium ion binding
				heparin binding
				protein binding
				structural molecule activity
3.06659		ATP-binding domain 1 family member B. [Uniprot/SWISSPROT;Acc:Q9H9Y4]		ATP binding
				nucleotide binding
3.07625		Tetraspanin-3 (Tspan-3) (Transmembrane 4 superfamily member 8) (Tetraspanin TM4-A). [Uniprot/SWISSPROT;Acc:O60637]	biological process	cell motility
				cell proliferation
			cellular component	integral to membrane
				membrane
3.11758		Growth/differentiation factor 2 precursor (GDF-2) (Bone morphogenetic protein 9) (BMP-9). [Uniprot/SWISSPROT;Acc:Q9UK05]	biological process	growth
			cellular component	extracellular region
				extracellular space
			molecular function	cytokine activity
				growth factor activity
3.14866	up	Transmembrane protein 181. [Uniprot/SWISSPROT;Acc:Q9P2C4]	cellular component	integral to membrane
				membrane

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.