MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Ratio	Regulation	description	Gene Ontology	Accession	Class	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2069 to 2118 of 2667 in total

Ratio	Regulation	description	Gene Ontology	Class
2.91954	up	Cisplatin resistance-associated overexpressed protein (cAMP regulatory element-associated protein 1) (CRE-associated protein 1) (CREAP-1) (Luc7A) (Okadaic acid-inducible phosphoprotein OA48-18). [Uniprot/SWISSPROT;Acc:O95232]	RNA splicing	biological process
2.93895	down	TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF). [Uniprot/SWISSPROT;Acc:Q92844]	cytoplasm	cellular component
			I-kappaB kinase/NF-kappaB cascade	biological process
			metal ion binding	molecular function
			protein binding
			signal transduction	biological process
			zinc ion binding	molecular function
2.95579	up	Protein phosphatase Slingshot homolog 3 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-3L) (hSSH-3L). [Uniprot/SWISSPROT;Acc:Q8TE77]	cytoplasm	cellular component
			cytoskeleton
			dephosphorylation	biological process
			hydrolase activity	molecular function
			nucleus	cellular component
			phosphoric monoester hydrolase activity	molecular function
			protein amino acid dephosphorylation	biological process
			protein tyrosine phosphatase activity	molecular function
			protein tyrosine/serine/threonine phosphatase activity
2.96739		Protein FRA10AC1. [Uniprot/SWISSPROT;Acc:Q70Z53]	nucleus	cellular component
			protein binding	molecular function
3.00923	down	Arylamine N-acetyltransferase 1 (EC 2.3.1.5) (Arylamide acetylase 1) (Monomorphic arylamine N-acetyltransferase) (MNAT) (N- acetyltransferase type 1) (NAT-1). [Uniprot/SWISSPROT;Acc:P18440]	acetyltransferase activity
			arylamine N-acetyltransferase activity
			cytoplasm	cellular component
			metabolic process	biological process
			transferase activity	molecular function
3.03423	up	Suppressor of G2 allele of SKP1 homolog (Sgt1) (Putative 40-6-3 protein). [Uniprot/SWISSPROT;Acc:Q9Y2Z0]	binding
			kinetochore	cellular component
			mitosis	biological process
			regulation of progression through cell cycle
			ubiquitin cycle
			ubiquitin ligase complex	cellular component
3.05037	down	Thrombospondin-4 precursor. [Uniprot/SWISSPROT;Acc:P35443]	calcium ion binding	molecular function
			cell adhesion	biological process
			extracellular region	cellular component
			heparin binding	molecular function
			protein binding
			proteinaceous extracellular matrix	cellular component
			structural molecule activity	molecular function
			substrate-bound cell migration, cell extension	biological process
3.06659		ATP-binding domain 1 family member B. [Uniprot/SWISSPROT;Acc:Q9H9Y4]	ATP binding	molecular function
			nucleotide binding
3.07625		Tetraspanin-3 (Tspan-3) (Transmembrane 4 superfamily member 8) (Tetraspanin TM4-A). [Uniprot/SWISSPROT;Acc:O60637]	cell motility	biological process
			cell proliferation
			integral to membrane	cellular component
			membrane
3.11758		Growth/differentiation factor 2 precursor (GDF-2) (Bone morphogenetic protein 9) (BMP-9). [Uniprot/SWISSPROT;Acc:Q9UK05]	cytokine activity	molecular function
			extracellular region	cellular component
			extracellular space
			growth	biological process
			growth factor activity	molecular function
3.14866	up	Transmembrane protein 181. [Uniprot/SWISSPROT;Acc:Q9P2C4]	integral to membrane	cellular component
			membrane

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.