MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Accession	Regulation	Ratio	Gene Ontology	Minimum Ratio	description	Class	Gene	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2069 to 2118 of 2667 in total

Regulation  : up

Ratio	Gene Ontology	description	Class
1.89308	protein transport	Ras-related protein Rab-36. [Uniprot/SWISSPROT;Acc:O95755]	biological process
	signal transduction
	small GTPase mediated signal transduction
1.93863	G-protein coupled receptor protein signaling pathway	Olfactory receptor 2B2 (Olfactory receptor 6-1) (OR6-1) (Hs6M1-10). [Uniprot/SWISSPROT;Acc:Q9GZK3]
	integral to membrane		cellular component
	membrane
	olfactory receptor activity		molecular function
	receptor activity
	response to stimulus		biological process
	rhodopsin-like receptor activity		molecular function
	sensory perception of smell		biological process
	signal transduction
1.93995	apoptosis	Zinc finger protein ubi-d4 (Requiem) (Apoptosis response zinc finger protein) (D4, zinc and double PHD fingers family 2). [Uniprot/SWISSPROT;Acc:Q92785]
	cytoplasm		cellular component
	induction of apoptosis by extracellular signals		biological process
	intracellular		cellular component
	metal ion binding		molecular function
	nucleic acid binding
	nucleus		cellular component
	protein binding		molecular function
	regulation of transcription, DNA-dependent		biological process
	transcription
	zinc ion binding		molecular function
1.95876	GTP binding	Ras-related protein Rab-17. [Uniprot/SWISSPROT;Acc:Q9H0T7]
	GTPase activity
	intracellular		cellular component
	intracellular protein transport		biological process
	nucleocytoplasmic transport
	nucleotide binding		molecular function
	protein binding
	protein transport		biological process
	signal transduction
	small GTPase mediated signal transduction
1.96673	endoplasmic reticulum	Signal peptidase complex catalytic subunit SEC11C (EC 3.4.-.-) (SEC11 homolog C) (SEC11-like protein 3) (Microsomal signal peptidase 21 kDa subunit) (SPase 21 kDa subunit) (SPC21). [Uniprot/SWISSPROT;Acc:Q9BY50]	cellular component
	integral to membrane
	membrane
	microsome
	peptidase activity		molecular function
	proteolysis		biological process
	serine-type peptidase activity		molecular function
	signal peptide processing		biological process
1.98149	anti-apoptosis	CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (TNF-related activation protein) (TRAP) (T cell antigen Gp39) (CD154 antigen) [Contains: CD40 ligand, membrane form; CD40 ligand, soluble form]. [Uniprot/SWISSPROT;Acc:P29965]
	B cell differentiation
	B cell proliferation
	CD40 receptor binding		molecular function
	cytokine activity
	extracellular space		cellular component
	immune response		biological process
	inflammatory response
	integral to membrane		cellular component

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.