MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Gene Ontology	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2019 to 2068 of 2667 in total

Regulation  : up

Ratio	description	Gene Ontology	Class
1.78439	Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta). [Uniprot/SWISSPROT;Acc:Q14839]	DNA binding	molecular function
		helicase activity
		hydrolase activity
		intracellular signaling cascade	biological process
		metal ion binding	molecular function
		nucleic acid binding
		nucleotide binding
		nucleus	cellular component
		protein binding	molecular function
		regulation of transcription from RNA polymerase II promoter	biological process
		transcription
		transcription factor binding	molecular function
		zinc ion binding
1.78708	Centromere protein L (CENP-L) (Interphase centromere complex protein 33). [Uniprot/SWISSPROT;Acc:Q8N0S6]	chromosome	cellular component
		chromosome, pericentric region
		nucleus
1.79094	Protein FAM65A. [Uniprot/SWISSPROT;Acc:Q6ZS17]	binding	molecular function
		intracellular	cellular component
		signal transduction	biological process
1.7961	RAS-like, family 11, member A [RefSeq_peptide;Acc:NP_996563]	GTP binding	molecular function
		intracellular	cellular component
		nucleotide binding	molecular function
		protein transport	biological process
		small GTPase mediated signal transduction
1.83496	Protein FAN (Factor associated with N-SMase activation) (Factor associated with neutral sphingomyelinase activation). [Uniprot/SWISSPROT;Acc:Q92636]	ceramide metabolic process
		cytoplasm	cellular component
		receptor signaling protein activity	molecular function
		signal transduction	biological process
		soluble fraction	cellular component
1.83601	coiled-coil domain containing 90A [RefSeq_peptide;Acc:NP_001026883]	G-protein coupled receptor protein signaling pathway	biological process
		integral to membrane	cellular component
		membrane
		mitochondrion
1.86433	CKLF-like MARVEL transmembrane domain-containing protein 4 (Chemokine- like factor superfamily member 4). [Uniprot/SWISSPROT;Acc:Q8IZR5]	ATP binding	molecular function
		ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
		cation transport	biological process
		chemotaxis
		cytokine activity	molecular function
		extracellular space	cellular component
		integral to membrane
		membrane
1.89308	Ras-related protein Rab-36. [Uniprot/SWISSPROT;Acc:O95755]	Golgi apparatus
		GTP binding	molecular function
		GTPase activity
		intracellular	cellular component
		intracellular protein transport	biological process
		membrane	cellular component
		nucleocytoplasmic transport	biological process
		nucleotide binding	molecular function
		protein binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.