MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Accession	Class	Gene Ontology	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2019 to 2068 of 2667 in total

Regulation  : up

Ratio	description	Class	Gene Ontology
1.78439	Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta). [Uniprot/SWISSPROT;Acc:Q14839]	molecular function	ATP binding
			ATP-dependent DNA helicase activity
			ATP-dependent helicase activity
			chromatin binding
			DNA binding
			helicase activity
			hydrolase activity
			metal ion binding
			nucleic acid binding
			nucleotide binding
			protein binding
			transcription factor binding
			zinc ion binding
1.78708	Centromere protein L (CENP-L) (Interphase centromere complex protein 33). [Uniprot/SWISSPROT;Acc:Q8N0S6]	cellular component	chromosome
			chromosome, pericentric region
			nucleus
1.79094	Protein FAM65A. [Uniprot/SWISSPROT;Acc:Q6ZS17]	biological process	signal transduction
		cellular component	intracellular
		molecular function	binding
1.7961	RAS-like, family 11, member A [RefSeq_peptide;Acc:NP_996563]	biological process	protein transport
			small GTPase mediated signal transduction
		cellular component	intracellular
		molecular function	GTP binding
			nucleotide binding
1.83496	Protein FAN (Factor associated with N-SMase activation) (Factor associated with neutral sphingomyelinase activation). [Uniprot/SWISSPROT;Acc:Q92636]	biological process	ceramide metabolic process
			signal transduction
		cellular component	cytoplasm
			soluble fraction
		molecular function	receptor signaling protein activity
1.83601	coiled-coil domain containing 90A [RefSeq_peptide;Acc:NP_001026883]	biological process	G-protein coupled receptor protein signaling pathway
		cellular component	integral to membrane
			membrane
			mitochondrion
1.86433	CKLF-like MARVEL transmembrane domain-containing protein 4 (Chemokine- like factor superfamily member 4). [Uniprot/SWISSPROT;Acc:Q8IZR5]	biological process	cation transport
			chemotaxis
		cellular component	extracellular space
			integral to membrane
			membrane
		molecular function	ATP binding
			ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
			cytokine activity
1.89308	Ras-related protein Rab-36. [Uniprot/SWISSPROT;Acc:O95755]	biological process	intracellular protein transport
			nucleocytoplasmic transport
			protein transport
			signal transduction
			small GTPase mediated signal transduction
		cellular component	Golgi apparatus
			intracellular
			membrane
		molecular function	GTP binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.