MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Accession	Gene Ontology	Regulation	description	Minimum Ratio	Class	Gene	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2019 to 2068 of 2667 in total

Ratio	Gene Ontology	Regulation	description	Class
2.86298	nucleus	up	T-brain-1 protein (T-box brain protein 1) (TBR-1) (TES-56). [Uniprot/SWISSPROT;Acc:Q16650]	cellular component
	regulation of transcription, DNA-dependent			biological process
	transcription
	transcription factor activity			molecular function
2.86538	cannabinoid receptor activity		Olfactory receptor 1J2 (Olfactory receptor OR9-19) (OST044) (HSA5) (HTPCRX15). [Uniprot/SWISSPROT;Acc:Q8NGS2]
	G-protein coupled receptor protein signaling pathway			biological process
	integral to membrane			cellular component
	olfactory receptor activity			molecular function
	receptor activity
	rhodopsin-like receptor activity
	sensory perception of smell			biological process
2.86965	ATP binding		RNA-binding protein 28 (RNA-binding motif protein 28). [Uniprot/SWISSPROT;Acc:Q9NW13]	molecular function
	chromosome			cellular component
	DNA binding			molecular function
	DNA topoisomerase (ATP-hydrolyzing) activity
	DNA topological change			biological process
	nucleic acid binding			molecular function
	nucleotide binding
	nucleus			cellular component
	RNA binding			molecular function
2.87038	calcium ion binding		Calpain-3 (EC 3.4.22.54) (Calpain L3) (Calpain p94) (Calcium-activated neutral proteinase 3) (CANP 3) (Muscle-specific calcium-activated neutral protease 3) (nCL-1). [Uniprot/SWISSPROT;Acc:P20807]
	calpain activity
	cysteine-type endopeptidase activity
	cytoplasm			cellular component
	intracellular
	muscle development			biological process
	nucleus			cellular component
	peptidase activity			molecular function
	protein binding
	proteolysis			biological process
	response to calcium ion
	response to drug
	sarcomere organization
	signal transducer activity			molecular function
2.88128	integral to membrane	down	CD302 antigen precursor (C-type lectin domain family 13 member A) (C- type lectin BIMLEC) (Type I transmembrane C-type lectin receptor DCL- 1). [Uniprot/SWISSPROT;Acc:Q8IX05]	cellular component
	membrane
	sugar binding			molecular function
2.88235	anion exchanger activity		Anion exchange protein 3 (Neuronal band 3-like protein) (Solute carrier family 4 member 3) (Cardiac/brain band 3-like protein) (CAE3/BAE3). [Uniprot/SWISSPROT;Acc:P48751]
	anion transport			biological process
	antiporter activity			molecular function
	inorganic anion exchanger activity
	integral to membrane			cellular component
	integral to plasma membrane
	membrane
	membrane fraction
2.91954	apoptosis	up	Cisplatin resistance-associated overexpressed protein (cAMP regulatory element-associated protein 1) (CRE-associated protein 1) (CREAP-1) (Luc7A) (Okadaic acid-inducible phosphoprotein OA48-18). [Uniprot/SWISSPROT;Acc:O95232]	biological process
	DNA binding			molecular function
	nucleus			cellular component
	protein binding			molecular function
	response to stress			biological process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.