MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Gene Ontology	Regulation	Accession	description	Class	Minimum Ratio	Gene	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 201 to 250 of 2667 in total

Ratio	Gene Ontology	Regulation	description	Class
1.18096	electron transport	down	Prostaglandin G/H synthase 2 precursor (EC 1.14.99.1) (Cyclooxygenase- 2) (COX-2) (Prostaglandin-endoperoxide synthase 2) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (PHS II). [Uniprot/SWISSPROT;Acc:P35354]	biological process
	endoplasmic reticulum			cellular component
	fatty acid biosynthetic process			biological process
	heme binding			molecular function
	iron ion binding
	membrane			cellular component
	metal ion binding			molecular function
	microsome			cellular component
	negative regulation of cell proliferation			biological process
	nucleus			cellular component
	oxidoreductase activity			molecular function
	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
	peroxidase activity
	prostaglandin-endoperoxide synthase activity
	protein binding
	protein complex			cellular component
	regulation of inflammatory response			biological process
	regulation of progression through cell cycle
	response to oxidative stress
1.18141	kinase activity		Ketosamine-3-kinase (EC 2.7.1.-) (Fructosamine-3-kinase-related protein). [Uniprot/SWISSPROT;Acc:Q9HA64]	molecular function
	transferase activity
1.18263	growth factor binding	up	Fibroblast growth factor-binding protein 3 precursor (FGF-binding protein 3) (FGF-BP3) (FGFBP-3). [Uniprot/SWISSPROT;Acc:Q8TAT2]
1.18489	cGMP biosynthetic process		Guanylate cyclase soluble subunit beta-2 (EC 4.6.1.2) (GCS-beta-2). [Uniprot/SWISSPROT;Acc:O75343]	biological process
	cyclic nucleotide biosynthetic process
	cytoplasm			cellular component
	guanylate cyclase activity			molecular function
	heme binding
	intracellular signaling cascade			biological process
	iron ion binding			molecular function
	metal ion binding
	phosphorus-oxygen lyase activity
1.18711	protein binding		NULL
1.18821	cytokine and chemokine mediated signaling pathway	down	Cytokine receptor common beta chain precursor (GM-CSF/IL-3/IL-5 receptor common beta-chain) (CD131 antigen) (CDw131). [Uniprot/SWISSPROT;Acc:P32927]	biological process
	granulocyte macrophage colony-stimulating factor receptor complex			cellular component
	hematopoietin/interferon-class (D200-domain) cytokine receptor activity			molecular function
	integral to membrane			cellular component
	interleukin receptor activity			molecular function
	interleukin-3 receptor activity
	interleukin-5 receptor activity
	membrane			cellular component
	receptor activity			molecular function
	respiratory gaseous exchange			biological process
	signal transduction
1.19117	cytoplasm	up	Ras-related GTP-binding protein D (Rag D). [Uniprot/SWISSPROT;Acc:Q9NQL2]	cellular component
	G-protein coupled receptor protein signaling pathway			biological process
	GTP binding			molecular function
	guanyl nucleotide binding
	nucleotide binding
	nucleus			cellular component
	protein binding			molecular function

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.