MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	Gene Ontology	description	Accession	Class	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1969 to 2018 of 2667 in total

Ratio	Regulation	Gene Ontology	description	Class
2.7017	up	neuropeptide hormone activity	Centromere protein S (CENP-S) (Apoptosis-inducing TAF9-like domain- containing protein 1). [Uniprot/SWISSPROT;Acc:Q8N2Z9]	molecular function
		nucleosome		cellular component
		nucleosome assembly		biological process
		nucleus		cellular component
		soluble fraction
		synaptic transmission		biological process
2.70687		calcium ion binding	Cartilage acidic protein 1 precursor (68 kDa chondrocyte-expressed protein) (CEP-68) (ASPIC). [Uniprot/SWISSPROT;Acc:Q9NQ79]	molecular function
		homoiothermy		biological process
		ice binding		molecular function
		intracellular		cellular component
		response to freezing		biological process
		ribosome		cellular component
		structural constituent of ribosome		molecular function
		translation		biological process
2.72371		Cajal body	Opa-interacting protein 5. [Uniprot/SWISSPROT;Acc:O43482]	cellular component
		cell communication		biological process
		cellular_component		cellular component
		chromatin
		chromocenter
		nucleus
		protein binding		molecular function
2.75048		centrosome	SAC3 domain containing 1 [RefSeq_peptide;Acc:NP_037431]	cellular component
		centrosome duplication		biological process
		spindle		cellular component
		spindle assembly		biological process
2.75351		cytoplasm	Protein phosphatase 1 regulatory subunit 14B (Phospholipase C beta 3 neighbouring gene protein). [Uniprot/SWISSPROT;Acc:Q96C90]	cellular component
		protein phosphatase inhibitor activity		molecular function
2.75593	down	protein modification process	ubiquilin-like [RefSeq_peptide;Acc:NP_659490]	biological process
2.79087		defense response	leucine-rich repeat neuronal 6A [RefSeq_peptide;Acc:NP_116197]
		integral to membrane		cellular component
		membrane
		protein binding		molecular function
2.83611		negative regulation of cell growth	SERTA domain-containing protein 3 (Replication protein-binding trans- activator) (RPA-binding trans-activator). [Uniprot/SWISSPROT;Acc:Q9UJW9]	biological process
		nucleus		cellular component
		positive regulation of transcription		biological process
		protein binding		molecular function
		regulation of transcription, DNA-dependent		biological process
		transcription
		transcriptional activator activity		molecular function
2.8521	up	calcium channel activity	transient receptor potential cation channel, subfamily M, member 1 [RefSeq_peptide;Acc:NP_002411]
		integral to plasma membrane		cellular component
		ion channel activity		molecular function
		ion transport		biological process
		membrane		cellular component
		membrane fraction
2.85383	down	integral to membrane	Uncharacterized protein C20orf142 precursor. [Uniprot/SWISSPROT;Acc:Q8N6M3]
		membrane
2.86298	up	brain development	T-brain-1 protein (T-box brain protein 1) (TBR-1) (TES-56). [Uniprot/SWISSPROT;Acc:Q16650]	biological process
		DNA binding		molecular function
		ligand-dependent nuclear receptor activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.