MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Regulation	Ratio	Gene Ontology	description	Accession	Class	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1951 to 2000 of 2667 in total

Regulation  : up

Ratio	Gene Ontology	description	Class
1.6384	olfactory receptor activity	Olfactory receptor 6S1. [Uniprot/SWISSPROT;Acc:Q8NH40]	molecular function
	receptor activity
	rhodopsin-like receptor activity
	signal transduction		biological process
1.63945	ATP binding	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK). [Uniprot/SWISSPROT;Acc:P31152]	molecular function
	cell cycle		biological process
	MAP kinase activity		molecular function
	nucleotide binding
	protein amino acid phosphorylation		biological process
	protein kinase activity		molecular function
	protein serine/threonine kinase activity
	protein-tyrosine kinase activity
	transferase activity
1.65422	intracellular	Uncharacterized protein C9orf117. [Uniprot/SPTREMBL;Acc:Q5JU67]	cellular component
	signal transduction		biological process
1.66123	G-protein coupled receptor protein signaling pathway	KRAB-A domain containing 1 (KRBA1), mRNA [RefSeq_dna;Acc:NM_032534]
	intracellular		cellular component
	membrane
	muscarinic acetylcholine receptor activity		molecular function
	nucleic acid binding
	regulation of transcription, DNA-dependent		biological process
1.66679	metal ion binding	TCDD-inducible poly [ADP-ribose] polymerase (EC 2.4.2.30) (Poly [ADP- ribose] polymerase 7) (PARP-7). [Uniprot/SWISSPROT;Acc:Q7Z3E1]	molecular function
	NAD+ ADP-ribosyltransferase activity
	nucleic acid binding
	nucleus		cellular component
	protein amino acid ADP-ribosylation		biological process
	protein binding		molecular function
	transferase activity, transferring glycosyl groups
	zinc ion binding
1.69345	DNA binding	GC-rich sequence DNA-binding factor (GCF) (Transcription factor 9) (TCF-9). [Uniprot/SWISSPROT;Acc:P16383]
	nucleus		cellular component
	regulation of transcription		biological process
	regulation of transcription, DNA-dependent
	RNA polymerase II transcription factor activity		molecular function
	transcription factor activity
1.69856	ATP binding	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2). [Uniprot/SWISSPROT;Acc:Q9H1R3]
	calmodulin binding
	cytoplasm		cellular component
	neuromuscular synaptic transmission		biological process
	nucleotide binding		molecular function
	protein amino acid phosphorylation		biological process
	protein kinase activity		molecular function
	protein serine/threonine kinase activity
	protein-tyrosine kinase activity
	transferase activity
1.73291	membrane	BTB/POZ domain-containing protein KCTD8. [Uniprot/SWISSPROT;Acc:Q6ZWB6]	cellular component
	potassium ion transport		biological process
	protein binding		molecular function
	voltage-gated potassium channel activity
	voltage-gated potassium channel complex		cellular component

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.