MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1951 to 2000 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
2.69364	up	Cytochrome P450 26A1 (EC 1.14.-.-) (Retinoic acid-metabolizing cytochrome) (P450 retinoic acid-inactivating 1) (P450RAI) (hP450RAI) (Retinoic acid 4-hydroxylase). [Uniprot/SWISSPROT;Acc:O43174]	biological process	retinoic acid receptor signaling pathway
			cellular component	endoplasmic reticulum
				membrane
				microsome
			molecular function	heme binding
				iron ion binding
				metal ion binding
				monooxygenase activity
				oxygen binding
				retinoic acid 4-hydroxylase activity
2.7017		Centromere protein S (CENP-S) (Apoptosis-inducing TAF9-like domain- containing protein 1). [Uniprot/SWISSPROT;Acc:Q8N2Z9]	biological process	chromosome organization and biogenesis (sensu Eukaryota)
				G-protein signaling, adenylate cyclase inhibiting pathway
				nucleosome assembly
				synaptic transmission
			cellular component	chromosome
				chromosome, pericentric region
				extracellular region
				nucleosome
				nucleus
				soluble fraction
			molecular function	DNA binding
				G-protein-coupled receptor binding
				hormone activity
				neuropeptide hormone activity
2.70687		Cartilage acidic protein 1 precursor (68 kDa chondrocyte-expressed protein) (CEP-68) (ASPIC). [Uniprot/SWISSPROT;Acc:Q9NQ79]	biological process	homoiothermy
				response to freezing
				translation
			cellular component	intracellular
				ribosome
			molecular function	calcium ion binding
				ice binding
				structural constituent of ribosome
2.72371		Opa-interacting protein 5. [Uniprot/SWISSPROT;Acc:O43482]	biological process	cell communication
			cellular component	Cajal body
				cellular_component
				chromatin
				chromocenter
				nucleus
			molecular function	protein binding
2.75048		SAC3 domain containing 1 [RefSeq_peptide;Acc:NP_037431]	biological process	centrosome duplication
				spindle assembly
			cellular component	centrosome
				spindle
2.75351		Protein phosphatase 1 regulatory subunit 14B (Phospholipase C beta 3 neighbouring gene protein). [Uniprot/SWISSPROT;Acc:Q96C90]		cytoplasm
			molecular function	protein phosphatase inhibitor activity
2.75593	down	ubiquilin-like [RefSeq_peptide;Acc:NP_659490]	biological process	protein modification process
2.79087		leucine-rich repeat neuronal 6A [RefSeq_peptide;Acc:NP_116197]		defense response
			cellular component	integral to membrane
				membrane
			molecular function	protein binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.