MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	Gene Ontology	description	Accession	Class	Minimum Ratio	Gene	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1951 to 2000 of 2667 in total

Ratio	Regulation	Gene Ontology	description	Class
2.69364	up	membrane	Cytochrome P450 26A1 (EC 1.14.-.-) (Retinoic acid-metabolizing cytochrome) (P450 retinoic acid-inactivating 1) (P450RAI) (hP450RAI) (Retinoic acid 4-hydroxylase). [Uniprot/SWISSPROT;Acc:O43174]	cellular component
		metabolic process		biological process
		metal ion binding		molecular function
		microsome		cellular component
		monooxygenase activity		molecular function
		neural crest cell development		biological process
		oxygen binding		molecular function
		retinoic acid 4-hydroxylase activity
		retinoic acid metabolic process		biological process
		retinoic acid receptor signaling pathway
2.7017		chromosome	Centromere protein S (CENP-S) (Apoptosis-inducing TAF9-like domain- containing protein 1). [Uniprot/SWISSPROT;Acc:Q8N2Z9]	cellular component
		chromosome organization and biogenesis (sensu Eukaryota)		biological process
		chromosome, pericentric region		cellular component
		DNA binding		molecular function
		extracellular region		cellular component
		G-protein signaling, adenylate cyclase inhibiting pathway		biological process
		G-protein-coupled receptor binding		molecular function
		hormone activity
		neuropeptide hormone activity
		nucleosome		cellular component
		nucleosome assembly		biological process
		nucleus		cellular component
		soluble fraction
		synaptic transmission		biological process
2.70687		calcium ion binding	Cartilage acidic protein 1 precursor (68 kDa chondrocyte-expressed protein) (CEP-68) (ASPIC). [Uniprot/SWISSPROT;Acc:Q9NQ79]	molecular function
		homoiothermy		biological process
		ice binding		molecular function
		intracellular		cellular component
		response to freezing		biological process
		ribosome		cellular component
		structural constituent of ribosome		molecular function
		translation		biological process
2.72371		Cajal body	Opa-interacting protein 5. [Uniprot/SWISSPROT;Acc:O43482]	cellular component
		cell communication		biological process
		cellular_component		cellular component
		chromatin
		chromocenter
		nucleus
		protein binding		molecular function
2.75048		centrosome	SAC3 domain containing 1 [RefSeq_peptide;Acc:NP_037431]	cellular component
		centrosome duplication		biological process
		spindle		cellular component
		spindle assembly		biological process
2.75351		cytoplasm	Protein phosphatase 1 regulatory subunit 14B (Phospholipase C beta 3 neighbouring gene protein). [Uniprot/SWISSPROT;Acc:Q96C90]	cellular component
		protein phosphatase inhibitor activity		molecular function
2.75593	down	protein modification process	ubiquilin-like [RefSeq_peptide;Acc:NP_659490]	biological process
2.79087		defense response	leucine-rich repeat neuronal 6A [RefSeq_peptide;Acc:NP_116197]
		integral to membrane		cellular component
		membrane
		protein binding		molecular function

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.