MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1901 to 1950 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
2.49031	up	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta). [Uniprot/SWISSPROT;Acc:Q99767]	biological process	protein transport
			molecular function	protein binding
2.4954		OMA1 homolog, zinc metallopeptidase [RefSeq_peptide;Acc:NP_660286]	biological process	proteolysis
			cellular component	membrane
			molecular function	metalloendopeptidase activity
				metallopeptidase activity
				zinc ion binding
2.51088	down	Epididymal-specific lipocalin-12 precursor. [Uniprot/SWISSPROT;Acc:Q6JVE5]	biological process	lipid metabolic process
				transport
			molecular function	binding
				structural constituent of cell wall
				transporter activity
2.54508	up	Neuroligin-2 precursor. [Uniprot/SWISSPROT;Acc:Q8NFZ4]	biological process	cell adhesion
				cell-cell adhesion
				intercellular junction maintenance
				synaptogenesis
			cellular component	integral to membrane
				membrane
				postsynaptic membrane
				synapse
			molecular function	cholinesterase activity
				neurexin binding
2.57202		Protein GPR107 precursor (Lung seven transmembrane receptor 1). [Uniprot/SWISSPROT;Acc:Q5VW38]	cellular component	integral to membrane
				membrane
2.58329	down	Myelin transcription factor 1-like protein (MyT1L protein) (MyT1-L). [Uniprot/SWISSPROT;Acc:Q9UL68]	biological process	cell differentiation
				multicellular organismal development
				nervous system development
				regulation of transcription, DNA-dependent
				transcription
			cellular component	nucleus
			molecular function	calcium ion binding
				metal ion binding
				transcription factor activity
				zinc ion binding
2.61135		28S ribosomal protein S35, mitochondrial precursor (S35mt) (MRP-S35) (Mitochondrial ribosomal protein S28) (MRP-S28). [Uniprot/SWISSPROT;Acc:P82673]	biological process	DNA damage response, detection of DNA damage
				peptide biosynthetic process
			cellular component	mitochondrial small ribosomal subunit
				mitochondrion
				ribonucleoprotein complex
2.65068	up	NULL	biological process	complement activation
				proteolysis
			cellular component	extracellular region
			molecular function	calcium ion binding
				serine-type endopeptidase activity
2.69364		Cytochrome P450 26A1 (EC 1.14.-.-) (Retinoic acid-metabolizing cytochrome) (P450 retinoic acid-inactivating 1) (P450RAI) (hP450RAI) (Retinoic acid 4-hydroxylase). [Uniprot/SWISSPROT;Acc:O43174]	biological process	anterior/posterior pattern formation
				central nervous system development
				electron transport
				metabolic process
				neural crest cell development
				retinoic acid metabolic process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.