MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Gene Ontology	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1901 to 1950 of 2667 in total

Ratio	Regulation	description	Gene Ontology	Class
2.49031	up	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta). [Uniprot/SWISSPROT;Acc:Q99767]	protein binding	molecular function
			protein transport	biological process
2.4954		OMA1 homolog, zinc metallopeptidase [RefSeq_peptide;Acc:NP_660286]	membrane	cellular component
			metalloendopeptidase activity	molecular function
			metallopeptidase activity
			proteolysis	biological process
			zinc ion binding	molecular function
2.51088	down	Epididymal-specific lipocalin-12 precursor. [Uniprot/SWISSPROT;Acc:Q6JVE5]	binding
			lipid metabolic process	biological process
			structural constituent of cell wall	molecular function
			transport	biological process
			transporter activity	molecular function
2.54508	up	Neuroligin-2 precursor. [Uniprot/SWISSPROT;Acc:Q8NFZ4]	cell adhesion	biological process
			cell-cell adhesion
			cholinesterase activity	molecular function
			integral to membrane	cellular component
			intercellular junction maintenance	biological process
			membrane	cellular component
			neurexin binding	molecular function
			postsynaptic membrane	cellular component
			synapse
			synaptogenesis	biological process
2.57202		Protein GPR107 precursor (Lung seven transmembrane receptor 1). [Uniprot/SWISSPROT;Acc:Q5VW38]	integral to membrane	cellular component
			membrane
2.58329	down	Myelin transcription factor 1-like protein (MyT1L protein) (MyT1-L). [Uniprot/SWISSPROT;Acc:Q9UL68]	calcium ion binding	molecular function
			cell differentiation	biological process
			metal ion binding	molecular function
			multicellular organismal development	biological process
			nervous system development
			nucleus	cellular component
			regulation of transcription, DNA-dependent	biological process
			transcription
			transcription factor activity	molecular function
			zinc ion binding
2.61135		28S ribosomal protein S35, mitochondrial precursor (S35mt) (MRP-S35) (Mitochondrial ribosomal protein S28) (MRP-S28). [Uniprot/SWISSPROT;Acc:P82673]	DNA damage response, detection of DNA damage	biological process
			mitochondrial small ribosomal subunit	cellular component
			mitochondrion
			peptide biosynthetic process	biological process
			ribonucleoprotein complex	cellular component
2.65068	up	NULL	calcium ion binding	molecular function
			complement activation	biological process
			extracellular region	cellular component
			proteolysis	biological process
			serine-type endopeptidase activity	molecular function
2.69364		Cytochrome P450 26A1 (EC 1.14.-.-) (Retinoic acid-metabolizing cytochrome) (P450 retinoic acid-inactivating 1) (P450RAI) (hP450RAI) (Retinoic acid 4-hydroxylase). [Uniprot/SWISSPROT;Acc:O43174]	anterior/posterior pattern formation	biological process
			central nervous system development
			electron transport
			endoplasmic reticulum	cellular component
			heme binding	molecular function
			iron ion binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.