MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	Gene Ontology	description	Class	Gene	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1901 to 1950 of 2667 in total

Regulation  : up

Ratio	Gene Ontology	description	Class
1.61987	elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)	Proteinase-activated receptor 1 precursor (PAR-1) (Thrombin receptor) (Coagulation factor II receptor). [Uniprot/SWISSPROT;Acc:P25116]	biological process
	establishment of synaptic specificity at neuromuscular junction
	G-protein coupled receptor activity		molecular function
	G-protein coupled receptor protein signaling pathway		biological process
	Golgi apparatus		cellular component
	integral to membrane
	integral to plasma membrane
	multicellular organismal development		biological process
	negative regulation of neuron apoptosis
	neuromuscular junction		cellular component
	plasma membrane
	positive regulation of calcium ion transport		biological process
	positive regulation of cell proliferation
	positive regulation of I-kappaB kinase/NF-kappaB cascade
	positive regulation of smooth muscle contraction
	positive regulation of vasoconstriction
	postsynaptic membrane		cellular component
	protein kinase C activation		biological process
	purinergic nucleotide receptor activity, G-protein coupled		molecular function
	receptor activity
	receptor binding
	regulation of progression through cell cycle		biological process
	regulation of sensory perception of pain
	release of sequestered calcium ion into cytosol
	response to wounding
	rhodopsin-like receptor activity		molecular function
	signal transduction		biological process
	STAT protein nuclear translocation
	thrombin receptor activity		molecular function
	tyrosine phosphorylation of STAT protein		biological process
1.62157	calcium ion binding	EF-hand domain-containing family member B. [Uniprot/SWISSPROT;Acc:Q8N7U6]	molecular function
1.62709	cytoplasmic vesicle	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14). [Uniprot/SWISSPROT;Acc:Q9H3S7]	cellular component
	dephosphorylation		biological process
	hydrolase activity		molecular function
	phosphoric monoester hydrolase activity
	protein amino acid dephosphorylation		biological process
	protein tyrosine phosphatase activity		molecular function
1.63639	biological_process	Cysteine-rich hydrophobic domain 2 protein (BrX-like translocated in leukemia). [Uniprot/SWISSPROT;Acc:Q9UKJ5]	biological process
	cellular_component		cellular component
	cytoplasmic vesicle
	Golgi apparatus
	Golgi-associated vesicle
	molecular_function		molecular function
	plasma membrane		cellular component
1.63713	binding	Armadillo repeat-containing X-linked protein 3 (Protein ALEX3) (ARM protein lost in epithelial cancers on chromosome X 3). [Uniprot/SWISSPROT;Acc:Q9UH62]	molecular function
	integral to membrane		cellular component
	membrane
1.6384	G-protein coupled receptor protein signaling pathway	Olfactory receptor 6S1. [Uniprot/SWISSPROT;Acc:Q8NH40]	biological process
	integral to membrane		cellular component
	membrane

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.