MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1868 to 1917 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
2.45383	down	40S ribosomal protein S2 (S4) (LLRep3 protein). [Uniprot/SWISSPROT;Acc:P15880]	cellular component	cytosolic small ribosomal subunit (sensu Eukaryota)
				intracellular
				ribosome
				small ribosomal subunit
			molecular function	RNA binding
				structural constituent of ribosome
2.45764	up	zinc transporter like 2 [RefSeq_peptide;Acc:NP_598003]	biological process	cation transport
				zinc ion transport
			cellular component	cytoplasmic membrane-bound vesicle
				Golgi apparatus
				membrane
			molecular function	cation transporter activity
				protein binding
				zinc ion transporter activity
2.45875		ADAMTS-19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 19) (ADAM-TS 19) (ADAM-TS19). [Uniprot/SWISSPROT;Acc:Q8TE59]	biological process	proteolysis
			cellular component	extracellular matrix
				intracellular
				proteinaceous extracellular matrix
			molecular function	metal ion binding
				metalloendopeptidase activity
				metallopeptidase activity
				nucleic acid binding
				peptidase activity
				zinc ion binding
2.48474		BET1 homolog (Golgi vesicular membrane-trafficking protein p18) (hBET1). [Uniprot/SWISSPROT;Acc:O15155]	biological process	ER to Golgi vesicle-mediated transport
				protein transport
			cellular component	endoplasmic reticulum
				Golgi apparatus
				Golgi membrane
				integral to membrane
				membrane
			molecular function	protein binding
2.49031		Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta). [Uniprot/SWISSPROT;Acc:Q99767]	biological process	nervous system development
				protein transport
			molecular function	protein binding
2.4954		OMA1 homolog, zinc metallopeptidase [RefSeq_peptide;Acc:NP_660286]	biological process	proteolysis
			cellular component	membrane
			molecular function	metalloendopeptidase activity
				metallopeptidase activity
				zinc ion binding
2.51088	down	Epididymal-specific lipocalin-12 precursor. [Uniprot/SWISSPROT;Acc:Q6JVE5]	biological process	lipid metabolic process
				transport
			molecular function	binding
				structural constituent of cell wall
				transporter activity
2.54508	up	Neuroligin-2 precursor. [Uniprot/SWISSPROT;Acc:Q8NFZ4]	biological process	cell adhesion
				cell-cell adhesion
				intercellular junction maintenance
				synaptogenesis
			cellular component	integral to membrane

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.