MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Class	Gene	Gene Ontology	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1801 to 1850 of 2667 in total

Regulation  : up

Ratio	description	Class	Gene Ontology
1.49264	Cytochrome P450 2W1 (EC 1.14.14.-) (CYPIIW1). [Uniprot/SWISSPROT;Acc:Q8TAV3]	cellular component	endoplasmic reticulum
			membrane
		molecular function	heme binding
			iron ion binding
			metal ion binding
			monooxygenase activity
			oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
1.49444	Ubiquitin-conjugating enzyme E2 R2 (EC 6.3.2.19) (Ubiquitin-protein ligase R2) (Ubiquitin carrier protein R2) (E2-CDC34B). [Uniprot/SWISSPROT;Acc:Q712K3]	biological process	protein modification process
			ubiquitin cycle
		molecular function	ligase activity
			small conjugating protein ligase activity
			ubiquitin-protein ligase activity
1.50206	LAG1 longevity assurance homolog 4. [Uniprot/SWISSPROT;Acc:Q9HA82]	biological process	ceramide biosynthetic process
			lipid biosynthetic process
			regulation of transcription, DNA-dependent
		cellular component	endoplasmic reticulum
			integral to membrane
			membrane
			nucleus
		molecular function	sequence-specific DNA binding
			transcription factor activity
1.54317	Dolichyl-phosphate beta-glucosyltransferase (EC 2.4.1.117) (DolP- glucosyltransferase). [Uniprot/SWISSPROT;Acc:Q9Y673]	biological process	determination of left/right symmetry
			protein amino acid glycosylation
		cellular component	endoplasmic reticulum
			integral to membrane
			membrane
		molecular function	dolichyl-phosphate beta-glucosyltransferase activity
			oligosaccharyl transferase activity
			transferase activity, transferring glycosyl groups
1.55844	TP53-target gene 5 protein (TP53-inducible gene 5 protein). [Uniprot/SWISSPROT;Acc:Q9Y2B4]	biological process	intracellular signaling cascade
			negative regulation of cell growth
		molecular function	molecular_function
1.56335	Zinc finger SWIM domain-containing protein 3. [Uniprot/SWISSPROT;Acc:Q96MP5]		metal ion binding
			zinc ion binding
1.57088	Forkhead box protein P2 (CAG repeat protein 44) (Trinucleotide repeat- containing gene 10 protein). [Uniprot/SWISSPROT;Acc:O15409]	biological process	caudate nucleus development
			putamen development
			regulation of transcription, DNA-dependent
			transcription
		cellular component	intracellular
			nucleus
		molecular function	metal ion binding
			nucleic acid binding
			protein homodimerization activity
			sequence-specific DNA binding
			transcription factor activity
			zinc ion binding
1.58115	Tetratricopeptide repeat protein 18 (TPR repeat protein 18). [Uniprot/SWISSPROT;Acc:Q5T0N1]		binding
1.59177	Transgelin-2 (SM22-alpha homolog). [Uniprot/SWISSPROT;Acc:P37802]	biological process	actomyosin structure organization and biogenesis
			muscle development
		molecular function	actin binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.