MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Gene	Gene Ontology	Minimum Ratio	Class	Maximum Ratio	Accession

Results: HTML CSV LaTeX

Showing element 1755 to 1804 of 2667 in total

Regulation  : up

Ratio	description	Gene Ontology	Class
1.45148	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372). [Uniprot/SWISSPROT;Acc:Q14789]	Golgi organization and biogenesis	biological process
		Golgi stack	cellular component
		integral to membrane
		membrane
		nucleus
		protein binding	molecular function
		regulation of transcription, DNA-dependent	biological process
		vesicle-mediated transport
1.45314	NULL	DNA binding	molecular function
1.45624	Transcription factor NF-E2 45 kDa subunit (Nuclear factor, erythroid- derived 2 45 kDa subunit) (p45 NF-E2) (Leucine zipper protein NF-E2). [Uniprot/SWISSPROT;Acc:Q16621]	circulation	biological process
		DNA binding	molecular function
		hemostasis	biological process
		multicellular organismal development
		nucleus	cellular component
		protein dimerization activity	molecular function
		regulation of transcription	biological process
		regulation of transcription from RNA polymerase II promoter
		regulation of transcription, DNA-dependent
		sequence-specific DNA binding	molecular function
		transcription coactivator activity
		transcription factor activity
1.45635	Cyclin-A2 (Cyclin-A). [Uniprot/SWISSPROT;Acc:P20248]	cell cycle	biological process
		cell division
		cytoplasm	cellular component
		female pronucleus
		male pronucleus
		mitosis	biological process
		mitotic G2 checkpoint
		nucleus	cellular component
		positive regulation of transcription	biological process
		protein binding	molecular function
		regulation of cyclin-dependent protein kinase activity	biological process
		regulation of progression through cell cycle
1.4628	Poliovirus receptor-related protein 3 precursor (Nectin-3) (CD113 antigen) (CDw113). [Uniprot/SWISSPROT;Acc:Q9NQS3]	apical junction complex	cellular component
		cell adhesion	biological process
		cell-cell adherens junction	cellular component
		homophilic cell adhesion	biological process
		integral to membrane	cellular component
		plasma membrane
		protein binding	molecular function
		protein homodimerization activity
		receptor activity
1.47697	Nck-associated protein 1-like (Membrane-associated protein HEM-1) (Hematopoietic protein 1). [Uniprot/SWISSPROT;Acc:P55160]	integral to plasma membrane	cellular component
		membrane
		membrane fraction
1.49264	Cytochrome P450 2W1 (EC 1.14.14.-) (CYPIIW1). [Uniprot/SWISSPROT;Acc:Q8TAV3]	electron transport	biological process
		endoplasmic reticulum	cellular component
		heme binding	molecular function
		iron ion binding
		membrane	cellular component

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.