MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1719 to 1768 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
1.98149	up	CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (TNF-related activation protein) (TRAP) (T cell antigen Gp39) (CD154 antigen) [Contains: CD40 ligand, membrane form; CD40 ligand, soluble form]. [Uniprot/SWISSPROT;Acc:P29965]	biological process	anti-apoptosis
				B cell differentiation
				B cell proliferation
				immune response
				inflammatory response
				isotype switching
				leukocyte adhesion
				platelet activation
				regulation of immunoglobulin secretion
			cellular component	extracellular space
				integral to membrane
				integral to plasma membrane
				membrane
				soluble fraction
			molecular function	CD40 receptor binding
				cytokine activity
				tumor necrosis factor receptor binding
2.07532		SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP). [Uniprot/SWISSPROT;Acc:Q9Y566]	biological process	cytoskeletal anchoring
			cellular component	cell junction
				cytoplasm
				dendrite
				intracellular
				membrane fraction
				postsynaptic membrane
				synapse
			molecular function	protein binding
2.08208	down	Inter-alpha-trypsin inhibitor heavy chain H2 precursor (ITI heavy chain H2) (Inter-alpha-inhibitor heavy chain 2) (Inter-alpha-trypsin inhibitor complex component II) (Serum-derived hyaluronan-associated protein) (SHAP). [Uniprot/SWISSPROT;Acc:P19823]	biological process	hyaluronan metabolic process
			cellular component	extracellular region
			molecular function	serine-type endopeptidase inhibitor activity
2.10428	up	Transcription factor AP-1 (Activator protein 1) (AP1) (Proto-oncogene c-jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39). [Uniprot/SWISSPROT;Acc:P05412]	biological process	cellular process
				leading edge cell differentiation
				negative regulation of protein amino acid autophosphorylation
				positive regulation of transcription from RNA polymerase II promoter
				regulation of progression through cell cycle
				regulation of transcription
				regulation of transcription, DNA-dependent
			cellular component	nuclear chromosome
				nucleus
				transcription factor complex
			molecular function	DNA binding
				protein dimerization activity
				RNA polymerase II transcription factor activity
				sequence-specific DNA binding
				transcription factor activity
2.11557	down	Echinoderm microtubule-associated protein-like 5 (EMAP-5). [Uniprot/SWISSPROT;Acc:Q05BV3]	cellular component	cytoplasm
				microtubule
2.12709		Ribonuclease P protein subunit p29 (EC 3.1.26.5) (hPOP4). [Uniprot/SWISSPROT;Acc:O95707]	biological process	rRNA processing
				tRNA processing
			cellular component	nucleus
				ribonuclease MRP complex

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.